{"title":"类风湿关节炎患者与托法替尼相关的静脉血栓栓塞事件:来自FAERS数据库的真实世界研究。","authors":"Jintuo Zhou, Ruihong Cai, Peiguang Niu, Tingting Chen, Guimu Guo, Xiaoping Zeng, Jinhua Zhang","doi":"10.1007/s00210-025-04642-6","DOIUrl":null,"url":null,"abstract":"<p><p>Tofacitinib, a Janus kinase (JAK) inhibitor approved in 2012, has become a pivotal oral treatment for rheumatoid arthritis (RA). However, the risk of venous thromboembolism (VTE) with tofacitinib in RA patients remains uncertain. This study aims to assess the association between tofacitinib use and the risk of VTE events in patients with RA using data from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). Additionally, this analysis sought to compare the reporting odds ratio (ROR) of VTE associated with tofacitinib and tumor necrosis factor inhibitors (TNFi). We conducted a retrospective pharmacovigilance study using FAERS data from the first quarter of 2012 to the fourth quarter of 2024. Disproportionality analysis was performed using ROR to evaluate the reporting risk of VTE events associated with tofacitinib compared with TNFi agents. A total of 1,786,456 adverse event reports related to RA were identified. Among these, 635 VTE events were associated with tofacitinib use and 1,354 VTE events were associated with TNFi agents. Tofacitinib was associated with a significantly elevated risk of VTE compared with the overall FAERS database (ROR 1.56, 95% CI 1.43-1.70) and with TNFi (ROR 2.20, 95% CI 2.00-2.40). Subgroup analysis revealed that the increased risk was particularly notable for pulmonary embolism (PE) (ROR 1.90, 95% CI 1.69-2.12) and deep vein thrombosis (DVT) (ROR 1.36, 95% CI 1.16-1.59). In this real-world study, tofacitinib use was associated with a higher reporting risk of VTE events compared with TNFi in RA patients. These findings underscore the need for careful patient selection and risk assessment when prescribing tofacitinib. Further prospective studies are warranted to confirm these associations and explore the underlying mechanisms.</p>","PeriodicalId":18876,"journal":{"name":"Naunyn-Schmiedeberg's archives of pharmacology","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Venous thromboembolism events associated with tofacitinib in rheumatoid arthritis patients: a real-world study from FAERS database.\",\"authors\":\"Jintuo Zhou, Ruihong Cai, Peiguang Niu, Tingting Chen, Guimu Guo, Xiaoping Zeng, Jinhua Zhang\",\"doi\":\"10.1007/s00210-025-04642-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tofacitinib, a Janus kinase (JAK) inhibitor approved in 2012, has become a pivotal oral treatment for rheumatoid arthritis (RA). However, the risk of venous thromboembolism (VTE) with tofacitinib in RA patients remains uncertain. This study aims to assess the association between tofacitinib use and the risk of VTE events in patients with RA using data from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). Additionally, this analysis sought to compare the reporting odds ratio (ROR) of VTE associated with tofacitinib and tumor necrosis factor inhibitors (TNFi). We conducted a retrospective pharmacovigilance study using FAERS data from the first quarter of 2012 to the fourth quarter of 2024. Disproportionality analysis was performed using ROR to evaluate the reporting risk of VTE events associated with tofacitinib compared with TNFi agents. A total of 1,786,456 adverse event reports related to RA were identified. Among these, 635 VTE events were associated with tofacitinib use and 1,354 VTE events were associated with TNFi agents. Tofacitinib was associated with a significantly elevated risk of VTE compared with the overall FAERS database (ROR 1.56, 95% CI 1.43-1.70) and with TNFi (ROR 2.20, 95% CI 2.00-2.40). Subgroup analysis revealed that the increased risk was particularly notable for pulmonary embolism (PE) (ROR 1.90, 95% CI 1.69-2.12) and deep vein thrombosis (DVT) (ROR 1.36, 95% CI 1.16-1.59). In this real-world study, tofacitinib use was associated with a higher reporting risk of VTE events compared with TNFi in RA patients. These findings underscore the need for careful patient selection and risk assessment when prescribing tofacitinib. 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引用次数: 0
摘要
托法替尼(Tofacitinib)是一种Janus激酶(JAK)抑制剂,于2012年获批,已成为治疗类风湿性关节炎(RA)的关键口服药物。然而,托法替尼在RA患者中静脉血栓栓塞(VTE)的风险仍不确定。本研究旨在利用美国食品和药物管理局(FDA)不良事件报告系统(FAERS)的数据,评估托法替尼使用与类风湿关节炎患者静脉血栓栓塞事件风险之间的关系。此外,本分析试图比较与托法替尼和肿瘤坏死因子抑制剂(TNFi)相关的静脉血栓栓塞的报告优势比(ROR)。我们使用2012年第一季度至2024年第四季度的FAERS数据进行了一项回顾性药物警戒研究。使用ROR进行歧化分析,以评估与TNFi药物相比,托法替尼与静脉血栓栓塞事件相关的报告风险。共发现了1,786,456例与RA相关的不良事件报告。其中,635例VTE事件与托法替尼的使用有关,1354例VTE事件与TNFi药物有关。与FAERS总体数据库(ROR 1.56, 95% CI 1.43-1.70)和TNFi (ROR 2.20, 95% CI 2.00-2.40)相比,托法替尼与VTE风险显著升高相关。亚组分析显示,肺栓塞(PE) (ROR 1.90, 95% CI 1.69-2.12)和深静脉血栓(DVT) (ROR 1.36, 95% CI 1.16-1.59)的风险增加尤其显著。在这项现实世界的研究中,与使用TNFi相比,在RA患者中使用托法替尼与更高的静脉血栓栓塞事件报告风险相关。这些发现强调了在处方托法替尼时需要仔细的患者选择和风险评估。需要进一步的前瞻性研究来证实这些关联并探索潜在的机制。
Venous thromboembolism events associated with tofacitinib in rheumatoid arthritis patients: a real-world study from FAERS database.
Tofacitinib, a Janus kinase (JAK) inhibitor approved in 2012, has become a pivotal oral treatment for rheumatoid arthritis (RA). However, the risk of venous thromboembolism (VTE) with tofacitinib in RA patients remains uncertain. This study aims to assess the association between tofacitinib use and the risk of VTE events in patients with RA using data from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). Additionally, this analysis sought to compare the reporting odds ratio (ROR) of VTE associated with tofacitinib and tumor necrosis factor inhibitors (TNFi). We conducted a retrospective pharmacovigilance study using FAERS data from the first quarter of 2012 to the fourth quarter of 2024. Disproportionality analysis was performed using ROR to evaluate the reporting risk of VTE events associated with tofacitinib compared with TNFi agents. A total of 1,786,456 adverse event reports related to RA were identified. Among these, 635 VTE events were associated with tofacitinib use and 1,354 VTE events were associated with TNFi agents. Tofacitinib was associated with a significantly elevated risk of VTE compared with the overall FAERS database (ROR 1.56, 95% CI 1.43-1.70) and with TNFi (ROR 2.20, 95% CI 2.00-2.40). Subgroup analysis revealed that the increased risk was particularly notable for pulmonary embolism (PE) (ROR 1.90, 95% CI 1.69-2.12) and deep vein thrombosis (DVT) (ROR 1.36, 95% CI 1.16-1.59). In this real-world study, tofacitinib use was associated with a higher reporting risk of VTE events compared with TNFi in RA patients. These findings underscore the need for careful patient selection and risk assessment when prescribing tofacitinib. Further prospective studies are warranted to confirm these associations and explore the underlying mechanisms.
期刊介绍:
Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.