从生态失调到长寿:肠道微生物群对衰老影响的叙述性回顾。

IF 12.1 2区 医学 Q1 CELL BIOLOGY
Ching-Hung Tseng, Chun-Ying Wu
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引用次数: 0

摘要

随着全球人口老龄化的加速,老龄化已成为一个重要的公共卫生问题。随着人们对延长寿命和健康寿命的追求越来越强烈,肠道微生物群引起了人们的关注,这是衰老过程中不可或缺但又可以改变的决定因素。本文叙述了肠道微生物群与衰老之间复杂的相互作用,并按逻辑顺序综合了研究结果。来自模式生物的证据支持肠道微生物对宿主衰老和寿命的因果影响。人类肠道微生物群在整个生命阶段的发育进化反映了其受饮食、生活方式、激素水平和免疫功能影响的适应性,在晚年通过肠道-肌肉和肠道-大脑轴调节衰老。长寿肠道微生物群的特征,包括增加的多样性、增加的有益类群和增强的肠道稳态,导致了延长寿命的策略。摄入纤维、有规律的锻炼和益生菌前/前/后补充剂是对肠道微生物群的潜在干预措施,可以促进晚年的活力。围绕这些相关主题,本综述确定了值得调查的问题,具有改善健康衰老治疗策略的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From dysbiosis to longevity: a narrative review into the gut microbiome's impact on aging.

Aging has become an important public health concern with the accelerated aging of the global population. The rising impetus to extend lifespan as well as healthspan has drawn attention to the gut microbiome, an indispensable yet modifiable determinant of the aging process. This narrative review addresses the complex interaction between the gut microbiome and aging, synthesizing findings in logical order. Evidence from model organisms supports the causal influence of gut microbes on host aging and longevity. Developmental evolution of the human gut microbiome throughout life stages reflects its adaptive nature affected by diet, lifestyle, hormone levels, and immune function, regulating aging through the gut-muscle and the gut-brain axes in late life. Signature characteristics of the long-lived gut microbiome, including increased diversity, elevated beneficial taxa, and enhanced gut homeostasis, lead to strategies to extend longevity. Intake of fiber, regular exercise, and pro-/pre-/postbiotic supplements are potential interventions on the gut microbiome to foster vitality in later years. Centering on these connected topics, this review identifies questions warranting investigation, with potential to improve therapeutic strategies for healthy aging.

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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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