用于单像素脉冲氧饱和度测量的双发射镧系有机发光二极管：从分子设计到器件级集成。

IF 3.4 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-10-10 DOI:10.1002/cmdc.202500465

Andrey I Kornikov, Makarii I Kozlov, Andrey A Vashchenko, Andrey A Poyarkov, Alexander S Goloveshkin, Egor V Latipov, Leonid S Lepnev, Valentina V Utochnikova

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引用次数: 0

摘要

有机发光二极管（oled）在红色和近红外区域具有双重发射，为简化脉搏血氧测量技术提供了突破性的机会。本文报道了一类新的双金属配合物Eu0.1Yb0.9(L)3Q （L = β-二酮酸酯；Q =中性配体），在612和978 nm同时发射，并对溶液处理oled进行了优化。基于Eu0.1Yb0.9(dbm)3thiadiazolophenanthroline （TDZP）的器件在两个光谱范围内都具有最高的电致发光强度，并被用作定制脉搏血氧仪原型的单像素光源。该样机演示了心率和血氧饱和度的实时测量，与商用设备完全一致。这是基于双发射镧系化合物的全功能oled血氧仪的首次演示。这一结果为使用先进发射材料和简化设备架构的下一代可穿戴生物医学传感器铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Dual-Emissive Lanthanide Organic light-emitting diode for Single-Pixel Pulse Oximetry: From Molecular Design to Device-Level Integration.

Organic light-emitting diodes (OLEDs) with dual emission in the red and near-infrared regions offer a breakthrough opportunity for simplifying pulse oximetry technology. Here, a new class of bimetallic complexes Eu_0.1Yb_0.9(L)₃Q (L = β-diketonates; Q = neutral ligands) with simultaneous emission at 612 and 978 nm has been reported, optimized for solution-processed OLEDs. A device based on Eu_0.1Yb_0.9(dbm)₃thiadiazolophenanthroline (TDZP) exhibits the highest electroluminescence intensity in both spectral ranges and is employed as a single-pixel light source in a custom-built pulse oximeter prototype. The prototype demonstrates real-time measurement of heart rate and blood oxygen saturation in full agreement with commercial devices. This is the first demonstration of a fully functional OLED-based oximeter relying on dual-emissive lanthanide complexes. This results pave the way for next-generation wearable biomedical sensors using advanced emissive materials and simplified device architectures.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.