子宫内暴露于对乙酰氨基酚和儿童注意缺陷多动障碍：一个持续的争议

IF 2.8 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2025-10-08 DOI:10.1016/j.reprotox.2025.109076

Per Damkier, Erika B. Gram

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引用次数: 0

摘要

儿童注意缺陷多动障碍（ADHD）与母亲使用对乙酰氨基酚（paracetamol， APAP）的关系仍然是一个持续的争议。在《自然心理健康》杂志最近的一篇论文中，Baker等人报道了儿童多动症与母亲在怀孕期间使用对乙酰氨基酚APAP有关。我们讨论了方法学的优势和局限性，以及本文对临床实践的影响程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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In utero exposure to acetaminophen and childhood attention deficit hyperactivity disorder: An ongoing controversy

Attention Deficit Hyperactivity Disorder (ADHD) in children as related to maternal use of acetaminophen (paracetamol, APAP) remains an ongoing controversy. In a recent paper in Nature Mental Health, Baker et al. reports on ADHD in children as related to maternal use of acetaminophen APAP in pregnancy. We discuss the methodological strengths and limitations and the extent to which this paper informs clinical practice.

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.