循环肿瘤组织修饰HPV DNA动力学在口咽鳞状细胞癌诱导治疗中的预测价值

IF 3.9 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-10-10 DOI:10.1016/j.oraloncology.2025.107746

Thangapandi Marudhupandi

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引用次数: 0

摘要

Tang等人最近的一项研究探讨了循环肿瘤组织修饰的HPV DNA （TTMV-HPV DNA）动力学在口咽鳞状细胞癌（OPSCC）诱导治疗中的预测作用。这表明液体活检生物标志物可以有效地评估治疗反应。通过跟踪HPV DNA的实时波动，该研究提供了一种非侵入性的方法来预测治疗结果，并增强患者对器官保存策略的选择。这凸显了循环生物标志物在推进个性化癌症治疗中的重要性。以下步骤应包括跨多个中心验证这些发现，将其与影像学和分子数据相结合，并进行前瞻性试验以确认其临床价值。总的来说，这项工作代表了针对hpv相关OPSCC的定制，生物标志物驱动治疗的重大进展。

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Predictive value of circulating tumor tissue-modified HPV DNA kinetics in induction therapy for oropharyngeal squamous cell carcinoma

A recent study by Tang et al. explores the predictive role of circulating tumor tissue-modified HPV DNA (TTMV-HPV DNA) kinetics during induction therapy in oropharyngeal squamous cell carcinoma (OPSCC). It demonstrates that liquid biopsy biomarkers can effectively evaluate treatment response. By tracking real-time fluctuations in HPV DNA, the study offers a non-invasive method to predict therapy outcomes and enhance patient selection for organ-preserving strategies. This highlights the increasing importance of circulating biomarkers in advancing personalized cancer treatment. The following steps should involve validating these findings across multiple centers, integrating them with imaging and molecular data, and conducting prospective trials to confirm their clinical value. Overall, this work represents a significant advancement toward tailored, biomarker-driven therapy for HPV-related OPSCC.

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.