伊朗西部犬的内脏利什曼病

IF 1.4 Q3 PARASITOLOGY

Veterinary parasitology, regional studies and reports Pub Date : 2025-10-01 DOI:10.1016/j.vprsr.2025.101351

Alireza Sazmand , Georgiana Deak , Ali Kalantari-Hesari , Pouria Rafiei , Navid Etemadi , Hesam Hajilou , Mina Malekmohammadi , Leili Moradi , Monireh Khordadmehr , Seyedmousa Motavallihaghi , Ali Fattahi-Bafghi , Mariaelisa Carbonara , Stephanie Oren , Domenico Otranto

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引用次数: 0

摘要

婴儿利什曼原虫是一种沙蝇传播的寄生虫，引起内脏和粘膜皮肤利什曼病。狗是主要的宿主，在感染的流行病学中起着至关重要的作用。本研究首次报道了来自伊朗西部省份的病犬中存在婴儿乳杆菌，以前认为该感染不是地方性的。从2024年4月到2025年6月，6只身体状况不佳和皮肤病变的杂种狗被送到伊朗Hamedan的兽医诊所。显微镜下检查疑似病变的印痕涂片和刮痕是否有利什曼原虫。并取2只死犬的脾脏、皮肤和淋巴结标本进行组织学检查。从皮肤损伤处提取基因组DNA，通过常规PCR和测序进一步检测利什曼原虫DNA。感染犬表现出多种临床症状，包括恶病质、肌肉萎缩、淋巴结病变、粘膜/皮肤病变、毛毛粗糙和干燥，秃发区以角化过度、结痂和鳞屑、脱屑、脂溢性皮炎和厚头皮屑为特征。在所有犬的组织学切片和/或印象涂片中观察到幼年利什曼原虫无鞭毛体，并通过DNA测序进一步证实。来自伊朗某地区的犬类中发现婴儿乳杆菌，此前该地区被认为不是地方性的，这凸显了在犬类种群中开展定期监测计划的重要性，以便实施控制和预防措施，以降低人类和动物环境中的感染风险。

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Visceral leishmaniosis in dogs from western Iran

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Visceral leishmaniosis in dogs from western Iran

Leishmania infantum is a sand fly-borne parasite, causing visceral and mucocutaneous leishmaniosis. Dogs are the main reservoir hosts and play a crucial role in the epidemiology of the infection. This study reports for the first time the presence of L. infantum in sick dogs from a western province of Iran, previously considered not endemic for this infection.

From April 2024 to June 2025, six mongrel dogs with poor body condition and skin lesions were presented to veterinary clinics in Hamedan, Iran. Impression smears and scrapes of the suspected lesions were examined microscopically for Leishmania amastigotes. In addition, spleen, skin, and lymph node samples from two dead dogs were collected for histological examination. Genomic DNA was extracted from skin lesions and further tested for Leishmania spp. DNA by conventional PCR and sequencing.

The infected dogs presented several clinical signs, including cachexia, muscle wasting, lymphadenopathy, muco−/cutaneous lesions, rough and dry hair coat, with alopecic regions characterized by hyperkeratosis, crusts and scales, desquamation, seborrheic dermatitis, and thick dandruff with bright reflections. Leishmania infantum amastigotes were observed in histological sections and/or impression smears of all dogs and further confirmed by DNA sequencing.

The presence of L. infantum in dogs from an area of Iran previously considered not endemic, spotlighting the importance of regular surveillance programs in canine populations for implementing control and preventive measures to reduce the risk of infection in both human and animal settings.

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来源期刊

Veterinary parasitology, regional studies and reports Multiple-

CiteScore

2.90

自引率

7.10%

发文量

126

审稿时长

97 days

期刊介绍： Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).