类风湿性关节炎爆发表现为假体关节感染，新一代滑膜测序指导治疗：一例报告

IF 2.1 Q3 ORTHOPEDICS

Arthroplasty Today Pub Date : 2025-10-01 DOI:10.1016/j.artd.2025.101875

Jonathan Lash MD, Andrew Murphy MD, Marcus Voigt MD, Alexander Burbelo BS, Matthew Bullock DO, MPT

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引用次数: 0

摘要

一例类风湿关节炎（RA）患者在接受全膝关节置换术几年后出现了类似假体关节感染的发作。停药后膝关节疼痛逐渐加重。炎症标志物升高，滑膜细胞计数增加，但滑膜液聚合酶链反应试验呈阴性。选择了非手术治疗方法，她恢复了RA药物治疗，导致症状缓解。下一代测序在排除感染和确定膝关节疼痛的风湿病原因方面发挥了关键作用，从而避免了不必要的翻修手术。下一代测序可能是一个有价值的诊断工具，在临床上模棱两可的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rheumatoid Arthritis Flare Presenting as Prosthetic Joint Infection With Synovial Next Generation Sequencing Guiding Treatment: A Case Report

A patient with rheumatoid arthritis (RA) experienced a flare that mimicked a prosthetic joint infection several years after undergoing total knee arthroplasty. She presented with gradual worsening knee pain following discontinuation of her RA medication. Elevated inflammatory markers and an increased synovial cell count were noted, but synovial fluid polymerase chain reaction testing was negative. A nonoperative treatment approach was chosen, and she resumed her RA medication which led to symptom resolution. Next-generation sequencing played a pivotal role in ruling out infection and identifying the rheumatic cause of the knee pain, thereby avoiding unnecessary revision surgery. Next-generation sequencing may be a valuable diagnostic tool in clinically ambiguous cases.

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来源期刊

Arthroplasty Today Medicine-Surgery

CiteScore

2.90

自引率

0.00%

发文量

258

审稿时长

40 weeks

期刊介绍： Arthroplasty Today is a companion journal to the Journal of Arthroplasty. The journal Arthroplasty Today brings together the clinical and scientific foundations for joint replacement of the hip and knee in an open-access, online format. Arthroplasty Today solicits manuscripts of the highest quality from all areas of scientific endeavor that relate to joint replacement or the treatment of its complications, including those dealing with patient outcomes, economic and policy issues, prosthetic design, biomechanics, biomaterials, and biologic response to arthroplasty. The journal focuses on case reports. It is the purpose of Arthroplasty Today to present material to practicing orthopaedic surgeons that will keep them abreast of developments in the field, prove useful in the care of patients, and aid in understanding the scientific foundation of this subspecialty area of joint replacement. The international members of the Editorial Board provide a worldwide perspective for the journal''s area of interest. Their participation ensures that each issue of Arthroplasty Today provides the reader with timely, peer-reviewed articles of the highest quality.