一种新型的多孔电化学平台用于地塞米松检测和递送以减轻急性肺损伤的焦亡

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-10-02 DOI:10.1016/j.matlet.2025.139604

Lili Jiang , Yan Shen , Fei Hao , Luming Zhu

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引用次数: 0

摘要

急性肺损伤（ALI）是一种危及生命的炎症性疾病，治疗选择有限。为了提高处理精度，我们开发了一种多功能纳米复合材料1-CS-TESPSA@CP1@Dex，集成了地塞米松递送和电化学检测。结构表征（拉曼光谱，红外光谱，扫描电镜）证实了组件的成功集成。该传感器灵敏度高（1.492 μA μM−1 cm−2），检出限低（0.035 μM），对Dex的选择性强。生物学评价显示低细胞毒性和良好的生物相容性。该系统为急性脑损伤的靶向治疗和实时监测提供了一种很有前景的方法。

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A novel porous electrochemical platform for dexamethasone detection and delivery to alleviate Pyroptosis in acute lung injury

Acute lung injury (ALI) is a life-threatening inflammatory condition with limited therapeutic options. To improve treatment precision, we developed a multifunctional nanocomposite, 1-CS-TESPSA@CP1@Dex, integrating dexamethasone delivery and electrochemical detection. Structural characterization (Raman, FT-IR, SEM) confirmed successful component integration. The modified GCE sensor showed high sensitivity (1.492 μA μM⁻¹ cm⁻²), low detection limit (0.035 μM), and strong selectivity for Dex. Biological evaluations demonstrated low cytotoxicity and good biocompatibility. This system offers a promising approach for targeted therapy and real-time monitoring in ALI.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive