Development and characterization of new dosimeter MAGIC-glutaraldehyde

This study presents the development of an advanced dosimetry system designed to outperform the conventional MAGIC polymer gel dosimeter. By incorporating Glutaraldehyde (GLA) as a cross-linking agent and employing X-ray computed tomography (CT) for precise three-dimensional dose readout, the modified MAGIC-G.LA gel dosimeter offers enhanced performance in radiotherapy simulations. To establish a calibration curve for the new formulation, irradiation doses ranging from 2 to 12 Gy were applied. The dose–response relationship exhibited superior linearity compared to the traditional MAGIC gel, with the calibration curve showing an excellent fit to a linear model (R² = 0.99). This improved linearity and sensitivity prompted further structural analyses to investigate the underlying mechanisms. Results suggest that Glutaraldehyde significantly contributes to the gel's enhanced polymerization response and structural stability under radiation. These findings provide deeper insight into the radiation-induced polymerization process and underscore the potential of Glutaraldehyde in optimizing polymer gel dosimetry.