钙离子纳米调节剂诱导肿瘤热凋亡的免疫治疗

IF 5.1 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Pub Date : 2025-10-11 DOI:10.1039/d5nr01897h

Fenggang Qi, Yuedong Guo, Yangxian Xu, Yanyan Liu, Ping Hu, Jianlin Shi

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引用次数: 0

摘要

焦亡是一种很有前途的肿瘤免疫治疗策略，但基于纳米材料的焦亡诱导剂仍未被充分开发。在这里，我们开发了一种ph响应钙纳米调节剂，通过将姜黄素加载到超薄的Ca/Al层状双氢氧化物纳米片（LDH-CUR）上。LDH-CUR通过线粒体钙超载诱导焦亡。姜黄素被肿瘤细胞吸收后，在酸性环境中降解，释放钙离子，姜黄素阻断钙的外排，导致钙激增。这触发活性氧的产生、细胞色素C的释放和caspase-3的激活。Caspase-3裂解气皮蛋白E (GSDME)，形成跨膜孔并诱导焦亡。焦亡释放炎症分子，激活强大的适应性免疫以靶向原发肿瘤并抑制转移。LDH-CUR展示了一种将焦亡诱导与免疫治疗相结合的新方法，为基于纳米材料的癌症治疗提供了潜力。

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Calcium Ion Nanomodulators Induce Pyroptosis for Tumor Immunotherapy

Pyroptosis is a promising strategy for tumor immunotherapy, but nanomaterial-based pyroptosis inducers remain underexplored. Here, we developed a pH-responsive calcium nanomodulator by loading curcumin onto ultrathin Ca/Al layered double hydroxide nanosheets (LDH-CUR). LDH-CUR induces pyroptosis via mitochondrial calcium overload. Upon internalization by tumor cells, it degrades in acidic environments, releasing calcium ions while curcumin blocks calcium efflux, leading to calcium surges. This triggers reactive oxygen species production, cytochrome C release, and caspase-3 activation. Caspase-3 cleaves gasdermin E (GSDME), forming transmembrane pores and inducing pyroptosis. Pyroptosis releases inflammatory molecules, activating robust adaptive immunity to target primary tumors and suppress metastases. LDH-CUR demonstrates a novel approach to combining pyroptosis induction with immunotherapy, offering potential for nanomaterial-based cancer treatments.

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来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.