女性抑郁、焦虑和神经质多基因风险评分与下尿路症状的关联

IF 25.2 1区医学 Q1 UROLOGY & NEPHROLOGY

European urology Pub Date : 2025-10-10 DOI:10.1016/j.eururo.2025.09.4154

Zayn Rajan, Christina Dardani, Kimberley Burrows, Oliver Bastiani, Marcus J. Drake, Carol Joinson

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引用次数: 0

摘要

背景和客观观察性研究发现，抑郁、焦虑和神经质可能与女性下尿路症状（LUTS）相关，但受混淆和测量误差的限制。我们研究了这些精神特征的遗传倾向是否与女性LUTS有关。方法研究对象来自雅芳父母与儿童纵向研究（ALSPAC）的母亲队列。使用全基因组关联研究的汇总数据计算抑郁、焦虑和神经质的多基因风险评分（PRSs）。LUTS采用两个时间点的有效问卷进行评估：2002-2004年（n = 4758；中位年龄40岁，四分位数间距[IQR] 37-43）和2011-2012年（n = 3026；中位年龄50岁，IQR 47-53）。拟合单独的逻辑回归模型，调整年龄和人口结构，以检验每个PRS与每个LUTS的关联。主要发现和局限性神经质性PRS在两个时间点均与夜尿相关[优势比和95%可信区间分别为1.24（1.10,1.40）和1.21(1.07,1.37)]，并与任何尿失禁（UI）、任何尿频和混合性尿失禁相关（2002-04）[分别为1.14（1.05,1.23）、1.12（1.02,1.23）和1.23(1.07,1.43)]。抑郁PRS与夜尿症[OR 1.33, 95% CI 1.17-1.50)和1.24(1.09,1.40)]和任何UI[1.09（1.01,1.18）相关；[1.11(1.02,1.20)]在两个时间点，并与任何紧急（2011-12）[1.13(1.03,1.24)]。焦虑性PRS与混合性UI相关（2002-04）[1.20(1.03,1.39)]。局限性包括PRS不能捕获所有的遗传倾向，潜在的多效性效应，以及对主要是欧洲血统的生育妇女的队列限制。结论和临床意义抑郁、焦虑和神经质的遗传倾向与女性LUTS的高风险相关。这一发现表明在LUTS的发展中存在潜在的共同病因或心理健康问题的可能贡献。

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Association of Polygenic Risk Scores for Depression, Anxiety, and Neuroticism with Lower Urinary Tract Symptoms Among Women

Background and objective

Observational studies have found that depression, anxiety, and neuroticism are prospectively associated with lower urinary tract symptoms (LUTS) among women, but are limited by confounding and measurement errors. We examined whether genetic liability for these psychiatric traits is associated with LUTS among women.

Methods

Participants were from the mothers cohort of the Avon Longitudinal Study of Parents and Children (ALSPAC). Polygenic risk scores (PRSs) for depression, anxiety, and neuroticism were calculated using summary data from genome-wide association studies. LUTS were assessed using validated questionnaires at two time points: 2002–2004 (n = 4758; median age 40 yr, interquartile range [IQR] 37–43) and 2011–2012 (n = 3026; median age 50 yr, IQR 47–53). Separate logistic regression models, adjusted for age and population structure, were fitted to examine the association of each PRS with each LUTS.

Key findings and limitations

The neuroticism PRS was associated with nocturia at both time points [odds ratio and 95% confidence intervals=1.24 (1.10,1.40) and 1.21 (1.07,1.37)], and with any urinary incontinence (UI), any urgency, and mixed UI (2002-04) [1.14 (1.05,1.23), 1.12 (1.02,1.23), and 1.23 (1.07,1.43), respectively]. The depression PRS was associated with nocturia [OR 1.33, 95% CI 1.17–1.50) and 1.24 (1.09,1.40)] and any UI [1.09 (1.01,1.18); 1.11 (1.02,1.20)] at both time points, and with any urgency (2011-12) [1.13 (1.03,1.24)]. The anxiety PRS was associated with mixed UI (2002-04) [1.20 (1.03,1.39)]. Limitations include PRS not capturing all genetic liability, potential pleiotropic effects, and restriction of the cohort to parous women of predominantly European ancestry.

Conclusions and clinical implications

Genetic liability for depression, anxiety, and neuroticism is associated with higher risk of LUTS among women. This finding indicates a potential shared aetiology or a possible contribution of mental health problems in the development of LUTS.

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来源期刊

European urology 医学-泌尿学与肾脏学

CiteScore

43.00

自引率

2.60%

发文量

1753

审稿时长

23 days

期刊介绍： European Urology is a peer-reviewed journal that publishes original articles and reviews on a broad spectrum of urological issues. Covering topics such as oncology, impotence, infertility, pediatrics, lithiasis and endourology, the journal also highlights recent advances in techniques, instrumentation, surgery, and pediatric urology. This comprehensive approach provides readers with an in-depth guide to international developments in urology.