年龄特异性肿瘤相关巨噬细胞生物标志物是甲状腺癌转移和免疫失调的基础。

IF 6 Q2 GERIATRICS & GERONTOLOGY
Tianyao Chu, Shenglong Xu, Hongyan Chen, Xinlei Zhang, Yan Zhao, Peng Zhang
{"title":"年龄特异性肿瘤相关巨噬细胞生物标志物是甲状腺癌转移和免疫失调的基础。","authors":"Tianyao Chu, Shenglong Xu, Hongyan Chen, Xinlei Zhang, Yan Zhao, Peng Zhang","doi":"10.1038/s41514-025-00270-9","DOIUrl":null,"url":null,"abstract":"<p><p>Thyroid cancer (THCA) shows rising incidence and aggressiveness in young-onset cases. Through integrated single-cell, transcriptomic, and proteomic analyses, we identified age-specific tumor-associated macrophage (TAM) genes, including OLR1 and SIGLEC1, linked to metastasis and immune dysfunction. These TAM biomarkers were validated at the protein level, highlighting their prognostic and therapeutic potential. Our findings reveal key TAM-driven mechanisms in young-onset THCA progression, warranting further clinical investigation.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"82"},"PeriodicalIF":6.0000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-specific tumor-associated macrophage biomarkers underlie metastasis and immune dysregulation in thyroid cancer.\",\"authors\":\"Tianyao Chu, Shenglong Xu, Hongyan Chen, Xinlei Zhang, Yan Zhao, Peng Zhang\",\"doi\":\"10.1038/s41514-025-00270-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Thyroid cancer (THCA) shows rising incidence and aggressiveness in young-onset cases. Through integrated single-cell, transcriptomic, and proteomic analyses, we identified age-specific tumor-associated macrophage (TAM) genes, including OLR1 and SIGLEC1, linked to metastasis and immune dysfunction. These TAM biomarkers were validated at the protein level, highlighting their prognostic and therapeutic potential. Our findings reveal key TAM-driven mechanisms in young-onset THCA progression, warranting further clinical investigation.</p>\",\"PeriodicalId\":94160,\"journal\":{\"name\":\"npj aging\",\"volume\":\"11 1\",\"pages\":\"82\"},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"npj aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41514-025-00270-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41514-025-00270-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

甲状腺癌(THCA)的发病率和侵袭性在年轻发病病例中呈上升趋势。通过综合单细胞、转录组学和蛋白质组学分析,我们确定了年龄特异性肿瘤相关巨噬细胞(TAM)基因,包括OLR1和SIGLEC1,与转移和免疫功能障碍有关。这些TAM生物标志物在蛋白质水平上得到了验证,突出了它们的预后和治疗潜力。我们的研究结果揭示了年轻发病THCA进展的关键tam驱动机制,值得进一步的临床研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-specific tumor-associated macrophage biomarkers underlie metastasis and immune dysregulation in thyroid cancer.

Thyroid cancer (THCA) shows rising incidence and aggressiveness in young-onset cases. Through integrated single-cell, transcriptomic, and proteomic analyses, we identified age-specific tumor-associated macrophage (TAM) genes, including OLR1 and SIGLEC1, linked to metastasis and immune dysfunction. These TAM biomarkers were validated at the protein level, highlighting their prognostic and therapeutic potential. Our findings reveal key TAM-driven mechanisms in young-onset THCA progression, warranting further clinical investigation.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
8.90
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信