Amanda Bangle, Danielle Williams, Jared Walters, Lan Nguyen
{"title":"围绝经期的认知功能:最新的系统综述和荟萃分析。","authors":"Amanda Bangle, Danielle Williams, Jared Walters, Lan Nguyen","doi":"10.1037/pag0000946","DOIUrl":null,"url":null,"abstract":"<p><p>Perimenopause is a transitional stage of reproductive aging characterized by fluctuating hormone levels which impact cognition. Cognitive concerns (e.g., forgetfulness, difficulty concentrating) are frequently reported during this stage and can affect daily functioning, work, and relationships. Numerous studies have reported that perimenopause is associated with subjective cognitive complaints and objective cognitive deficits; however, findings have been inconsistent due to methodological variability including different comparison groups (premenopause/postmenopause) and different outcomes investigated (attention, memory, etc.). This systematic review and meta-analytic investigation therefore sought to provide clarity by exploring differences in cognition during perimenopause compared to both premenopause and postmenopause. Across 26 articles comprising 9,428 participants, group differences were examined between perimenopausal and premenopausal women (21 studies), and between perimenopausal and postmenopausal women (21 studies). Overall, perimenopausal women exhibited poorer cognitive outcomes than premenopausal women (moderate effect), though, notably, this negative effect was only found in studies utilizing the Stages of Reproductive Aging Workshop (STRAW+10) criteria to categorize menopausal/reproductive stages. In contrast, no differences were found between perimenopausal and postmenopausal women, though moderator analyses indicated that studies not utilizing the STRAW+10 criteria yielded significant effects (better cognition in perimenopausal than postmenopausal groups). Additionally, compared to postmenopausal women, perimenopausal women demonstrated better objective cognitive outcomes (accuracy, reaction time), with a trend for poorer self-reported outcomes. These findings highlight the importance of applying standardized reproductive staging (STRAW+10) and the inclusion of subjective and objective assessments in future research. A clearer understanding of cognitive changes during perimenopause may improve clinical assessment and inform interventions to support cognitive health in midlife women. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":48426,"journal":{"name":"Psychology and Aging","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cognitive functioning in perimenopause: An updated systematic review and meta-analysis.\",\"authors\":\"Amanda Bangle, Danielle Williams, Jared Walters, Lan Nguyen\",\"doi\":\"10.1037/pag0000946\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Perimenopause is a transitional stage of reproductive aging characterized by fluctuating hormone levels which impact cognition. Cognitive concerns (e.g., forgetfulness, difficulty concentrating) are frequently reported during this stage and can affect daily functioning, work, and relationships. Numerous studies have reported that perimenopause is associated with subjective cognitive complaints and objective cognitive deficits; however, findings have been inconsistent due to methodological variability including different comparison groups (premenopause/postmenopause) and different outcomes investigated (attention, memory, etc.). This systematic review and meta-analytic investigation therefore sought to provide clarity by exploring differences in cognition during perimenopause compared to both premenopause and postmenopause. Across 26 articles comprising 9,428 participants, group differences were examined between perimenopausal and premenopausal women (21 studies), and between perimenopausal and postmenopausal women (21 studies). Overall, perimenopausal women exhibited poorer cognitive outcomes than premenopausal women (moderate effect), though, notably, this negative effect was only found in studies utilizing the Stages of Reproductive Aging Workshop (STRAW+10) criteria to categorize menopausal/reproductive stages. In contrast, no differences were found between perimenopausal and postmenopausal women, though moderator analyses indicated that studies not utilizing the STRAW+10 criteria yielded significant effects (better cognition in perimenopausal than postmenopausal groups). Additionally, compared to postmenopausal women, perimenopausal women demonstrated better objective cognitive outcomes (accuracy, reaction time), with a trend for poorer self-reported outcomes. These findings highlight the importance of applying standardized reproductive staging (STRAW+10) and the inclusion of subjective and objective assessments in future research. A clearer understanding of cognitive changes during perimenopause may improve clinical assessment and inform interventions to support cognitive health in midlife women. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>\",\"PeriodicalId\":48426,\"journal\":{\"name\":\"Psychology and Aging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychology and Aging\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1037/pag0000946\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychology and Aging","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1037/pag0000946","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
围绝经期是生殖衰老的过渡阶段,其特征是激素水平波动,影响认知。认知问题(如健忘、注意力难以集中)在这一阶段经常被报道,并可能影响日常功能、工作和人际关系。许多研究报道,围绝经期与主观认知抱怨和客观认知缺陷有关;然而,由于方法的可变性,包括不同的对照组(绝经前/绝经后)和不同的研究结果(注意力、记忆力等),研究结果并不一致。因此,本系统综述和荟萃分析研究旨在通过探索围绝经期与绝经前和绝经后的认知差异来提供清晰的信息。在包含9428名参与者的26篇文章中,研究了围绝经期和绝经前妇女(21项研究)以及围绝经期和绝经后妇女(21项研究)之间的组差异。总体而言,围绝经期妇女表现出比绝经前妇女更差的认知结果(中等影响),尽管值得注意的是,这种负面影响仅在使用生殖衰老阶段研讨会(STRAW+10)标准对绝经/生殖阶段进行分类的研究中发现。相比之下,围绝经期妇女和绝经后妇女之间没有发现差异,尽管调节分析表明,不使用STRAW+10标准的研究产生了显著的影响(围绝经期妇女的认知能力比绝经后妇女更好)。此外,与绝经后妇女相比,围绝经期妇女表现出更好的客观认知结果(准确性,反应时间),有较差的自我报告结果的趋势。这些发现强调了在未来的研究中应用标准化生殖分期(STRAW+10)和纳入主观和客观评估的重要性。更清楚地了解围绝经期的认知变化可能会改善临床评估,并为支持中年妇女认知健康的干预措施提供信息。(PsycInfo Database Record (c) 2025 APA,版权所有)。
Cognitive functioning in perimenopause: An updated systematic review and meta-analysis.
Perimenopause is a transitional stage of reproductive aging characterized by fluctuating hormone levels which impact cognition. Cognitive concerns (e.g., forgetfulness, difficulty concentrating) are frequently reported during this stage and can affect daily functioning, work, and relationships. Numerous studies have reported that perimenopause is associated with subjective cognitive complaints and objective cognitive deficits; however, findings have been inconsistent due to methodological variability including different comparison groups (premenopause/postmenopause) and different outcomes investigated (attention, memory, etc.). This systematic review and meta-analytic investigation therefore sought to provide clarity by exploring differences in cognition during perimenopause compared to both premenopause and postmenopause. Across 26 articles comprising 9,428 participants, group differences were examined between perimenopausal and premenopausal women (21 studies), and between perimenopausal and postmenopausal women (21 studies). Overall, perimenopausal women exhibited poorer cognitive outcomes than premenopausal women (moderate effect), though, notably, this negative effect was only found in studies utilizing the Stages of Reproductive Aging Workshop (STRAW+10) criteria to categorize menopausal/reproductive stages. In contrast, no differences were found between perimenopausal and postmenopausal women, though moderator analyses indicated that studies not utilizing the STRAW+10 criteria yielded significant effects (better cognition in perimenopausal than postmenopausal groups). Additionally, compared to postmenopausal women, perimenopausal women demonstrated better objective cognitive outcomes (accuracy, reaction time), with a trend for poorer self-reported outcomes. These findings highlight the importance of applying standardized reproductive staging (STRAW+10) and the inclusion of subjective and objective assessments in future research. A clearer understanding of cognitive changes during perimenopause may improve clinical assessment and inform interventions to support cognitive health in midlife women. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
期刊介绍:
Psychology and Aging publishes original articles on adult development and aging. Such original articles include reports of research that may be applied, biobehavioral, clinical, educational, experimental (laboratory, field, or naturalistic studies), methodological, or psychosocial. Although the emphasis is on original research investigations, occasional theoretical analyses of research issues, practical clinical problems, or policy may appear, as well as critical reviews of a content area in adult development and aging. Clinical case studies that have theoretical significance are also appropriate. Brief reports are acceptable with the author"s agreement not to submit a full report to another journal.