基底细胞癌的不典型表现:上臂的巨大疣状溃疡。

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-10-04 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S553586
Jianzhong Zhang, Ying Guo, Chao Lv, Zhifeng Li, Guoying Miao, Litao Wang
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引用次数: 0

摘要

巨细胞基底细胞癌(GBCC)是一种罕见的临床侵袭性亚型。我们报告一个不寻常的情况下,71岁的男性与30年的历史,一个缓慢扩大的肿瘤,他的左臂伸肌表面。病变表现为巨大的不规则溃疡,尺寸为12×10 cm,边界呈聚结性疣状。组织病理学检查证实了诊断,发现真皮内有特征性的基底样细胞巢,外周栅栏和间质退缩伪影。免疫组化染色Ber-EP4、CK15、Ki-67、Bcl-2阳性。患者被诊断为GBCC合并溃疡。左肱骨计算机断层扫描和腋窝淋巴结超声检查未发现转移迹象。患者经慢莫氏显微摄影手术治疗成功。随后对切除标本的组织病理学评估证实无肿瘤边缘。随访12个月,未见局部复发。本病例强调了在罕见部位识别GBCC的重要性,并证明了慢Mohs技术在实现大而复杂肿瘤的完全切除方面的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An Atypical Presentation of Basal Cell Carcinoma: A Giant Verrucous Ulcer on the Upper Arm.

An Atypical Presentation of Basal Cell Carcinoma: A Giant Verrucous Ulcer on the Upper Arm.

An Atypical Presentation of Basal Cell Carcinoma: A Giant Verrucous Ulcer on the Upper Arm.

Giant basal cell carcinoma (GBCC) is a rare and clinically aggressive subtype of BCC. We report an unusual case of a 71-year-old male with a 30-year history of a slowly enlarging tumor on the extensor surface of his left upper arm. The lesion presented as a giant, irregular ulceration measuring 12×10 cm with coalescing verrucous borders. Histopathological examination confirmed the diagnosis, revealing characteristic nests of basaloid cells with peripheral palisading and stromal retraction artifact in the dermis. Immunohistochemical staining was positive for Ber-EP4, CK15, Ki-67, Bcl-2. The patient was diagnosed with GBCC with Ulcer. Staging workup with computed tomography (CT) of the left humerus and axillary lymph node ultrasonography showed no evidence of metastasis. The patient was successfully treated with slow Mohs micrographic surgery. Subsequent histopathological assessment of the excised specimen confirmed tumor-free margins. At 12-month follow-up, no local recurrence was observed. This case highlights the importance of recognizing GBCC in uncommon locations and demonstrates the efficacy of slow Mohs technique for achieving complete excision in large, complex tumors.

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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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