光遗传学作为控制鸡胚胎发生过程中可兴奋和不可兴奋组织的有用工具。

IF 2.1 3区生物学 Q2 DEVELOPMENTAL BIOLOGY

Developmental biology Pub Date : 2025-10-09 DOI:10.1016/j.ydbio.2025.10.004

Masafumi Inaba, Yuuki Shikaya , Yoshiko Takahashi

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引用次数: 0

摘要

光遗传学作为一种以无创方式控制细胞兴奋性的现代工具，在神经科学中得到了广泛的应用。近年来，光遗传学方法开始应用于其他生物现象的研究，包括肌肉功能。对于这些分析，鸡胚胎是一个很好的模型动物，因为它们非常适合光遗传学基因（如通道视紫红质）及其后续靶向光照射的位点特异性操作。本文综述了利用鸡胚胎进行光遗传学研究的最新进展，重点介绍了轴突寻路、肠道蠕动和羽毛形态发生的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Optogenetics as a useful tool to control excitable and non-excitable tissues during chicken embryogenesis

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Optogenetics as a useful tool to control excitable and non-excitable tissues during chicken embryogenesis

Optogenetics, a modern tool to control cellular excitability in a non-invasive way, has widely been used in neuroscience. Recently, optogenetic approaches begin to be applied to studies of other biological phenomena including muscle functions. For these analyses, chicken embryos serve as an excellent model animal since they are highly amenable to site-specific manipulations with genes of optogenetics such as Channelrhodopsins, and its following targeted light irradiation. We here overview recent progresses in optogenetics using chicken embryos with a highlight on the studies of axon pathfinding, gut peristalsis, and feather morphogenesis.

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来源期刊

Developmental biology 生物-发育生物学

CiteScore

5.30

自引率

3.70%

发文量

182

审稿时长

1.5 months

期刊介绍： Developmental Biology (DB) publishes original research on mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning, cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals.