{"title":"维生素D血液水平和维生素D受体多态性与小儿重症急性呼吸综合征冠状病毒2急性后后遗症的严重程度有关","authors":"Pei-Chi Chen, Yu-Lung Hsu, Yen-Hsi Chen, Chih-Yu Lin, Miao-Hsi Hsieh, Hui-Ju Tsai, Wen-Shuo Kuo, Hui-Fang Kao, Shulhn-Der Wang, Yu-Shan Ho, Cheng-Ye Cai, Lawrence Shih-Hsin Wu, Jiu-Yao Wang","doi":"10.1016/j.clnesp.2025.09.033","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aims: </strong>Vitamin D, through the vitamin D receptor (VDR), modulates immune responses and may reduce inflammation linked to prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) symptoms. While vitamin D deficiency is tied to severe Coronavirus disease 2019 (COVID-19) outcomes, its role in post-acute sequelae of SARS-CoV-2 (PASC) is unclear. This study examines the relationship between PASC severity in children and their vitamin D levels or VDR genetic variants.</p><p><strong>Methods: </strong>Children with persistent and prolonged symptoms following SARS-CoV-2 infection were recruited from a hospital. A detailed questionnaire was administered, and blood samples were collected for comprehensive biomedical test. Deoxyribonucleic acid (DNA) from peripheral blood mononuclear cells (PBMCs) of the enrolled patients was extracted for genotyping of VDR genetic variants. The effects of vitamin D levels and VDR genetic variants on PASC severity were analyzed.</p><p><strong>Results: </strong>A total of 123 patients were enrolled in the study, with 90 completing the PASC severity survey and 109 providing results from biomedical tests. Vitamin D levels showed a significant negative correlation with PASC scores (p = 0.0052). There was a significant positive correlation (p < 0.05) between vitamin D levels and both lactate dehydrogenase (LDH) and aspartate amino transferase (AST), while neutrophils, lymphocytes, and eosinophils demonstrated a significant negative correlation (p < 0.05) with vitamin D levels. Patients with the GG genotype of the VDR genetic variant rs2228570 had lower PASC scores compared to those with the AA or AG genotypes. The highest PASC scores were observed in patients with 25-hydroxyvitamin D [25(OH)D] levels <20 ng/ml and the AA/AG genotype.</p><p><strong>Conclusions: </strong>Both vitamin D levels and VDR genetic variants contribute to the severity of PASC in children, with a combined additive effect on the condition's severity.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":"303-308"},"PeriodicalIF":2.6000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Vitamin D blood levels and vitamin D receptor polymorphisms contribute to post-acute sequelae of severe acute respiratory syndrome coronavirus 2 severity in the pediatric patients.\",\"authors\":\"Pei-Chi Chen, Yu-Lung Hsu, Yen-Hsi Chen, Chih-Yu Lin, Miao-Hsi Hsieh, Hui-Ju Tsai, Wen-Shuo Kuo, Hui-Fang Kao, Shulhn-Der Wang, Yu-Shan Ho, Cheng-Ye Cai, Lawrence Shih-Hsin Wu, Jiu-Yao Wang\",\"doi\":\"10.1016/j.clnesp.2025.09.033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and aims: </strong>Vitamin D, through the vitamin D receptor (VDR), modulates immune responses and may reduce inflammation linked to prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) symptoms. While vitamin D deficiency is tied to severe Coronavirus disease 2019 (COVID-19) outcomes, its role in post-acute sequelae of SARS-CoV-2 (PASC) is unclear. This study examines the relationship between PASC severity in children and their vitamin D levels or VDR genetic variants.</p><p><strong>Methods: </strong>Children with persistent and prolonged symptoms following SARS-CoV-2 infection were recruited from a hospital. A detailed questionnaire was administered, and blood samples were collected for comprehensive biomedical test. Deoxyribonucleic acid (DNA) from peripheral blood mononuclear cells (PBMCs) of the enrolled patients was extracted for genotyping of VDR genetic variants. The effects of vitamin D levels and VDR genetic variants on PASC severity were analyzed.</p><p><strong>Results: </strong>A total of 123 patients were enrolled in the study, with 90 completing the PASC severity survey and 109 providing results from biomedical tests. Vitamin D levels showed a significant negative correlation with PASC scores (p = 0.0052). There was a significant positive correlation (p < 0.05) between vitamin D levels and both lactate dehydrogenase (LDH) and aspartate amino transferase (AST), while neutrophils, lymphocytes, and eosinophils demonstrated a significant negative correlation (p < 0.05) with vitamin D levels. Patients with the GG genotype of the VDR genetic variant rs2228570 had lower PASC scores compared to those with the AA or AG genotypes. The highest PASC scores were observed in patients with 25-hydroxyvitamin D [25(OH)D] levels <20 ng/ml and the AA/AG genotype.</p><p><strong>Conclusions: </strong>Both vitamin D levels and VDR genetic variants contribute to the severity of PASC in children, with a combined additive effect on the condition's severity.</p>\",\"PeriodicalId\":10352,\"journal\":{\"name\":\"Clinical nutrition ESPEN\",\"volume\":\" \",\"pages\":\"303-308\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical nutrition ESPEN\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.clnesp.2025.09.033\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.clnesp.2025.09.033","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Vitamin D blood levels and vitamin D receptor polymorphisms contribute to post-acute sequelae of severe acute respiratory syndrome coronavirus 2 severity in the pediatric patients.
Background and aims: Vitamin D, through the vitamin D receptor (VDR), modulates immune responses and may reduce inflammation linked to prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) symptoms. While vitamin D deficiency is tied to severe Coronavirus disease 2019 (COVID-19) outcomes, its role in post-acute sequelae of SARS-CoV-2 (PASC) is unclear. This study examines the relationship between PASC severity in children and their vitamin D levels or VDR genetic variants.
Methods: Children with persistent and prolonged symptoms following SARS-CoV-2 infection were recruited from a hospital. A detailed questionnaire was administered, and blood samples were collected for comprehensive biomedical test. Deoxyribonucleic acid (DNA) from peripheral blood mononuclear cells (PBMCs) of the enrolled patients was extracted for genotyping of VDR genetic variants. The effects of vitamin D levels and VDR genetic variants on PASC severity were analyzed.
Results: A total of 123 patients were enrolled in the study, with 90 completing the PASC severity survey and 109 providing results from biomedical tests. Vitamin D levels showed a significant negative correlation with PASC scores (p = 0.0052). There was a significant positive correlation (p < 0.05) between vitamin D levels and both lactate dehydrogenase (LDH) and aspartate amino transferase (AST), while neutrophils, lymphocytes, and eosinophils demonstrated a significant negative correlation (p < 0.05) with vitamin D levels. Patients with the GG genotype of the VDR genetic variant rs2228570 had lower PASC scores compared to those with the AA or AG genotypes. The highest PASC scores were observed in patients with 25-hydroxyvitamin D [25(OH)D] levels <20 ng/ml and the AA/AG genotype.
Conclusions: Both vitamin D levels and VDR genetic variants contribute to the severity of PASC in children, with a combined additive effect on the condition's severity.
期刊介绍：
Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.
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