超声辅助水中[3 + 2]环加成合成具有抗癌活性的吡咯利西啶和吲哚利西啶融合支架

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-10-09 DOI:10.1002/ejoc.202500690

Kaushal Naithani, Arka Das, Mendragutti Shireesha, Mamta Kumari, Subhadeep Roy, Subhendu Bhowmik

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引用次数: 0

摘要

报道了一种超声辅助的水中分子内（3 + 2）环加成反应，用于合成吡咯利西啶和吲哚利西啶融合骨架。这种方法消除了有机溶剂，苛刻的试剂和高温的需要。通过克级合成证明了该方法的实用性，并证明了所得到的化合物对三阴性乳腺癌细胞系的抗癌特性。

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Ultrasound-Assisted In-Water [3 + 2] Cycloaddition for the Synthesis of Fused Pyrrolizidine and Indolizidine Scaffolds with Anticancer Activity

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Ultrasound-Assisted In-Water [3 + 2] Cycloaddition for the Synthesis of Fused Pyrrolizidine and Indolizidine Scaffolds with Anticancer Activity

An ultrasound-assisted in-water intramolecular (3 + 2) cycloaddition reaction is reported for the synthesis of fused-pyrrolizidine and indolizidine frameworks. This approach eliminates the need for organic solvents, harsh reagents, and high temperatures. The method's practicality is demonstrated by gram-scale synthesis, and the anticancer properties of the resulting compounds against the triple-negative breast cancer cell line are demonstrated.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.