基于聚（2-乙基-2-恶唑啉）的aie活性光敏剂，具有聚集增强的活性氧，用于有效的光动力治疗

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-10 DOI:10.1039/d5cc03883a

Yuan Wang, Yuqin Xu, Jiawei Gu, Yanlong Zhong, Duoduo Wei, Meiying Liu, Qianyong Cao, Shaorong Huang, Xiaoyong Zhang, Yen Wei

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引用次数: 0

摘要

开发具有增强聚合态活性氧（ROS）生成能力的高效光敏剂（ps）是有效光动力治疗（PDT）的关键。本研究首次利用氨基炔键合化学方法，与聚集诱导发射（AIE）活性PS （TPA-T-yne）偶联，设计了两亲性聚（2-乙基-2-恶唑啉）基共聚物（PN-TPA-yne）。所得到的PN-TPA-yne形成了具有强大AIE和高效ROS生成的水溶性纳米组件，从而提高了PDT效率，解决了传统PDT的主要问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A poly(2-ethyl-2-oxazoline)-based AIE-active photosensitizer with aggregation-enhanced reactive oxygen species for efficient photodynamic therapy

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A poly(2-ethyl-2-oxazoline)-based AIE-active photosensitizer with aggregation-enhanced reactive oxygen species for efficient photodynamic therapy

Developing efficient photosensitizers (PSs) with enhanced reactive oxygen species (ROS) generation capability in the aggregated state is essential for effective photodynamic therapy (PDT). Here, we designed an amphiphilic poly(2-ethyl-2-oxazoline)-based copolymer (PN-TPA-yne) for the first time by conjugating with aggregation-induced emission (AIE)-active PS (TPA-T-yne) using amino-yne click chemistry. The resultant PN-TPA-yne forms water-soluble nano-assemblies with robust AIE and efficient ROS generation, thereby enhancing PDT efficacy and resolving the major issues of conventional PSs.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.