David M Yen, Greg E Davis, Randall A Ow, Ellen M O'Malley, Anthony G Del Signore
{"title":"多点阻抗控制射频消融鼻后神经治疗慢性鼻炎后两年的临床疗效。","authors":"David M Yen, Greg E Davis, Randall A Ow, Ellen M O'Malley, Anthony G Del Signore","doi":"10.1177/01455613251382759","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>A person's quality of life can be deeply impacted by chronic rhinitis. We report 2-year outcomes in patients after treatment using a novel, multipoint, impedance-controlled, radiofrequency ablation device.</p><p><strong>Methods: </strong>A prospective, multicenter, single-arm clinical study of posterior nasal nerve ablation in adults with chronic rhinitis. Efficacy assessments included the reflective total nasal symptom score (rTNSS), postnasal drip, cough, Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7), nasal obstruction symptom evaluation (NOSE), and mini-Rhinoconjunctivitis Quality of Life Questionnaire (mini-RQLQ).</p><p><strong>Results: </strong>Seventy-five of 80 (94%) participants completed 2-year follow-up. Statistically significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life as evidenced by the mean change in rTNSS (-4.3), postnasal drip (-0.9), cough (-0.7), ETDQ-7 (-1.1), NOSE (-31.7), and mini-RQLQ (-1.7; <i>P</i> < .0001 for all). Allergic and nonallergic rhinitis subgroups demonstrated similar, significant improvement. No serious related adverse events were reported between the 9-month and 2-year follow-ups.</p><p><strong>Conclusions: </strong>The data demonstrate consistent long-term efficacy and safety of a multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. Significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life through 2-year follow-up.</p><p><strong>Study registration: </strong>www.</p><p><strong>Clinicaltrials: </strong>gov. Unique identifier NCT05591989.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251382759"},"PeriodicalIF":0.7000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two-Year Clinical Outcomes After Multipoint Impedance-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Treatment of Chronic Rhinitis.\",\"authors\":\"David M Yen, Greg E Davis, Randall A Ow, Ellen M O'Malley, Anthony G Del Signore\",\"doi\":\"10.1177/01455613251382759\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>A person's quality of life can be deeply impacted by chronic rhinitis. We report 2-year outcomes in patients after treatment using a novel, multipoint, impedance-controlled, radiofrequency ablation device.</p><p><strong>Methods: </strong>A prospective, multicenter, single-arm clinical study of posterior nasal nerve ablation in adults with chronic rhinitis. Efficacy assessments included the reflective total nasal symptom score (rTNSS), postnasal drip, cough, Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7), nasal obstruction symptom evaluation (NOSE), and mini-Rhinoconjunctivitis Quality of Life Questionnaire (mini-RQLQ).</p><p><strong>Results: </strong>Seventy-five of 80 (94%) participants completed 2-year follow-up. Statistically significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life as evidenced by the mean change in rTNSS (-4.3), postnasal drip (-0.9), cough (-0.7), ETDQ-7 (-1.1), NOSE (-31.7), and mini-RQLQ (-1.7; <i>P</i> < .0001 for all). Allergic and nonallergic rhinitis subgroups demonstrated similar, significant improvement. No serious related adverse events were reported between the 9-month and 2-year follow-ups.</p><p><strong>Conclusions: </strong>The data demonstrate consistent long-term efficacy and safety of a multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. Significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life through 2-year follow-up.</p><p><strong>Study registration: </strong>www.</p><p><strong>Clinicaltrials: </strong>gov. Unique identifier NCT05591989.</p>\",\"PeriodicalId\":93984,\"journal\":{\"name\":\"Ear, nose, & throat journal\",\"volume\":\" \",\"pages\":\"1455613251382759\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ear, nose, & throat journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/01455613251382759\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ear, nose, & throat journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/01455613251382759","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Two-Year Clinical Outcomes After Multipoint Impedance-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Treatment of Chronic Rhinitis.
Objective: A person's quality of life can be deeply impacted by chronic rhinitis. We report 2-year outcomes in patients after treatment using a novel, multipoint, impedance-controlled, radiofrequency ablation device.
Methods: A prospective, multicenter, single-arm clinical study of posterior nasal nerve ablation in adults with chronic rhinitis. Efficacy assessments included the reflective total nasal symptom score (rTNSS), postnasal drip, cough, Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7), nasal obstruction symptom evaluation (NOSE), and mini-Rhinoconjunctivitis Quality of Life Questionnaire (mini-RQLQ).
Results: Seventy-five of 80 (94%) participants completed 2-year follow-up. Statistically significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life as evidenced by the mean change in rTNSS (-4.3), postnasal drip (-0.9), cough (-0.7), ETDQ-7 (-1.1), NOSE (-31.7), and mini-RQLQ (-1.7; P < .0001 for all). Allergic and nonallergic rhinitis subgroups demonstrated similar, significant improvement. No serious related adverse events were reported between the 9-month and 2-year follow-ups.
Conclusions: The data demonstrate consistent long-term efficacy and safety of a multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. Significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life through 2-year follow-up.