Patricia Olga Andres, Elizabeth Madsen, Analía Laura Fernández
{"title":"实体器官移植后结核:阿根廷某三级医院的临床经验。","authors":"Patricia Olga Andres, Elizabeth Madsen, Analía Laura Fernández","doi":"10.1016/j.ram.2025.09.001","DOIUrl":null,"url":null,"abstract":"<p><p>Tuberculosis in solid organ transplant (SOT) recipients is a clinical challenge. This opportunistic infection has atypical presentations and raises concerns due to both the toxicity of antifimic drugs and their interaction with immunosuppressive therapy that may result in graft loss or death. This retrospective review of cases of active tuberculosis after SOT describes the management of this infection in a hospital in Argentina. Between January 2006 and June 2022, 27 transplanted patients had positive cultures for the Mycobacterium tuberculosis complex. Their median age was 56 years; 78% were male. Ten (37%) patients had extra-pulmonary or disseminated tuberculosis. Twenty-five (93%) patients required invasive procedures to reach a diagnosis. In 17 (63%) patients, the initial diagnosis was based on a positive Ziehl-Neelsen smear. Twenty-four patients received a four-drug induction treatment without rifampin. Clinical cure was 80% and crude mortality was 20%.</p>","PeriodicalId":21163,"journal":{"name":"Revista Argentina de microbiologia","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tuberculosis after solid organ transplantation: Clinical experience in a tertiary hospital from Argentina.\",\"authors\":\"Patricia Olga Andres, Elizabeth Madsen, Analía Laura Fernández\",\"doi\":\"10.1016/j.ram.2025.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tuberculosis in solid organ transplant (SOT) recipients is a clinical challenge. This opportunistic infection has atypical presentations and raises concerns due to both the toxicity of antifimic drugs and their interaction with immunosuppressive therapy that may result in graft loss or death. This retrospective review of cases of active tuberculosis after SOT describes the management of this infection in a hospital in Argentina. Between January 2006 and June 2022, 27 transplanted patients had positive cultures for the Mycobacterium tuberculosis complex. Their median age was 56 years; 78% were male. Ten (37%) patients had extra-pulmonary or disseminated tuberculosis. Twenty-five (93%) patients required invasive procedures to reach a diagnosis. In 17 (63%) patients, the initial diagnosis was based on a positive Ziehl-Neelsen smear. Twenty-four patients received a four-drug induction treatment without rifampin. Clinical cure was 80% and crude mortality was 20%.</p>\",\"PeriodicalId\":21163,\"journal\":{\"name\":\"Revista Argentina de microbiologia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Argentina de microbiologia\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ram.2025.09.001\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Argentina de microbiologia","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.ram.2025.09.001","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Tuberculosis after solid organ transplantation: Clinical experience in a tertiary hospital from Argentina.
Tuberculosis in solid organ transplant (SOT) recipients is a clinical challenge. This opportunistic infection has atypical presentations and raises concerns due to both the toxicity of antifimic drugs and their interaction with immunosuppressive therapy that may result in graft loss or death. This retrospective review of cases of active tuberculosis after SOT describes the management of this infection in a hospital in Argentina. Between January 2006 and June 2022, 27 transplanted patients had positive cultures for the Mycobacterium tuberculosis complex. Their median age was 56 years; 78% were male. Ten (37%) patients had extra-pulmonary or disseminated tuberculosis. Twenty-five (93%) patients required invasive procedures to reach a diagnosis. In 17 (63%) patients, the initial diagnosis was based on a positive Ziehl-Neelsen smear. Twenty-four patients received a four-drug induction treatment without rifampin. Clinical cure was 80% and crude mortality was 20%.
期刊介绍:
La Revista Argentina de Microbiología es una publicación trimestral editada por la Asociación Argentina de Microbiología y destinada a la difusión de trabajos científicos en las distintas áreas de la Microbiología. La Asociación Argentina de Microbiología se reserva los derechos de propiedad y reproducción del material aceptado y publicado.