在英国生物库中,情绪处理过程中杏仁核功能磁共振成像的规范性反应是抑郁症状的一个特征。

IF 5.5 2区 医学 Q1 PSYCHIATRY
Jerke J van den Berg, Henricus G Ruhé, Henk A Marquering, Liesbeth Reneman, Matthan W A Caan
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引用次数: 0

摘要

背景:在情绪处理过程中,杏仁核反应性增高被认为是临床抑郁症的潜在生物标志物。然而,尚不清楚这是否也适用于一般人群的抑郁症状,并且-在复发性抑郁发作后缓解-它与未来的发作有关。方法:利用英国生物银行人群研究(n = 11,334),我们研究了负面面部刺激时杏仁核反应的相关性,重点研究了终生抑郁(特征)、抑郁症状(状态)以及抗抑郁药(AD)治疗对其的调节作用。我们采用规范模型(NM)来更好地纳入杏仁核活动的群体异质性。结果:与先前的研究一致,过去2周的抑郁症状(状态)与杏仁核反应性信号无关。相反,我们的研究结果表明,杏仁核反应与抑郁发作(特征)的复发之间存在显著的正相关(p = 0.03, ω2 = 0.001)。纵向分析显示,之前经历过一次抑郁发作的组在再次发作后杏仁核反应显着增加(p = 0.03, ω2 = 0.017)。ad与杏仁核反应不直接相关,但与发作复发严重程度的相关性降低。结论:杏仁核对负面刺激的反应与个体抑郁发作复发的风险相关,而AD治疗降低了这种关联。这项研究强调了杏仁核反应性作为一种特征的相关性,而不是(复发性)抑郁症的状态生物标志物。此外,它还展示了在人口数据上下文中应用NM的好处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Normative amygdala fMRI response during emotional processing as a trait of depressive symptoms in the UK Biobank.

Background: Heightened reactivity in the amygdala measured by functional magnetic resonance imaging during emotional processing is considered a potential biomarker for clinical depression. Still, it is unknown whether this is also true for depressive symptoms in the general population, and - when in remission after recurrent depressive episodes - it is associated with future episodes.

Methods: Using the UK Biobank population study (n = 11,334), we investigated the association of amygdala reactivity during negative facial stimuli, focusing on lifetime depression (trait), depressive symptoms (state), and the modulating effect of antidepressant (AD) treatment thereof. We employed normative modeling (NM) to better incorporate population heterogeneity of the amygdala activity.

Results: In line with a previous study, depressive symptoms (state) over the last 2 weeks were not associated with the amygdala reactivity signal. Rather, our results indicate a significant positive association (p = 0.03, ω2 = 0.001) between amygdala response and the recurrence of depressive episodes (trait). Longitudinal analysis revealed that the group that had experienced a single depressive episode before showed a significantly increased amygdala response after additional episodes (p = 0.03, ω2 = 0.017). ADs were not associated with amygdala response directly, but decreased associations within episode recurrence severity.

Conclusions: The amygdala response to negative stimuli was associated with an individual's risk of recurrence of depressive episodes, and AD treatment reduced these associations. This study highlights the relevance of amygdala reactivity as a trait, but not a state biomarker for (recurrent) depression. Moreover, it demonstrates the benefit of applying NM in the context of population data.

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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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