从早期到晚期肝期的路径，将基因减毒寄生虫作为疟疾疫苗接种策略。

IF 6.5 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-10-08 DOI:10.1038/s41541-025-01265-z

O A C Lamers, B M D Franke-Fayard, M Roestenberg, J M M Krol

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引用次数: 0

摘要

在肝脏发育阶段停止的基因减毒寄生虫（gap）显示出作为疟疾疫苗的巨大潜力。与恶性疟原虫在24-48小时后捕获（早期捕获者）相比，寄生虫在6-7天后捕获（晚期捕获者）显示出更优越的效果，这突出了肝期免疫在促进无菌保护方面的重要性。在这里，我们描述了在人体中测试的gap和导致其产生的临床前研究。我们讨论现有gap的安全性和有效性，特别关注其作为疟疾疫苗的大规模实施。

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The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy.

Genetically attenuated parasites (GAPs) that arrest during liver stage development have shown significant potential as malaria vaccines. Compared to Plasmodium falciparum GAPs that arrest after 24-48 h (early-arresters), parasites arresting after 6-7 days (late-arresters) have shown superior efficacy, highlighting the importance of liver stage immunity in promoting sterile protection. Here, we describe GAPs tested in humans and the pre-clinical research that led to their creation. We discuss safety and efficacy of existing GAPs with particular focus on their large-scale implementation as malaria vaccines.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.