Xinpeng Wang, Xiaoyu Li, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han
{"title":"儿童可逆性脾损害综合征的新病因及临床特点。","authors":"Xinpeng Wang, Xiaoyu Li, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han","doi":"10.1007/s10072-025-08554-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To describe causes, clinical manifestations, imaging features and prognosis of reversible splenial lesion syndrome (RESLES) in children.</p><p><strong>Methods: </strong>A total of 36 patients with RESLES hospitalized in Children's Hospital of Chongqing Medical University between January 1, 2017 and Mar 31, 2024 were included. The clinical features including the causes, clinical manifestations and prognosis were statistically analyzed.</p><p><strong>Results: </strong>The patients' ages ranged from 16 to 170 months with a median age of 49 months. Of the 36 patients, 24 patients were RESLES type-1 (the lesions were limited to SCC) and 12 patients were RESLES type-2(the lesions spread to other parts of the corpus callosum, extensive brain white matter, or both). The participating causes included infection, chemotherapy, immunoglobulin A vasculitis, autoimmune glial fibrillary acidic protein astrocytopathy, hypertension and hypoparathyroidism. The common neurological symptoms were seizures(n = 27), headache(n = 10), dizziness(n = 6), altered consciousness(n = 8), and psychologico-behavioral abnormalities(n = 14). Most patients had a good prognosis except 1 patient remained in a state of minimal consciousness during the follow-up.</p><p><strong>Conclusion: </strong>This research demonstrates some possible causes of RESLES. Patients with RESLES present with a variety of nonspecific symptoms and most of them had a good prognosis.</p><p><strong>Significance: </strong>These findings are groundbreaking to a deeper understanding of RESLES.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Some novel causes and clinical characteristics of reversible splenial lesion syndrome- found in children.\",\"authors\":\"Xinpeng Wang, Xiaoyu Li, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han\",\"doi\":\"10.1007/s10072-025-08554-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To describe causes, clinical manifestations, imaging features and prognosis of reversible splenial lesion syndrome (RESLES) in children.</p><p><strong>Methods: </strong>A total of 36 patients with RESLES hospitalized in Children's Hospital of Chongqing Medical University between January 1, 2017 and Mar 31, 2024 were included. The clinical features including the causes, clinical manifestations and prognosis were statistically analyzed.</p><p><strong>Results: </strong>The patients' ages ranged from 16 to 170 months with a median age of 49 months. Of the 36 patients, 24 patients were RESLES type-1 (the lesions were limited to SCC) and 12 patients were RESLES type-2(the lesions spread to other parts of the corpus callosum, extensive brain white matter, or both). The participating causes included infection, chemotherapy, immunoglobulin A vasculitis, autoimmune glial fibrillary acidic protein astrocytopathy, hypertension and hypoparathyroidism. The common neurological symptoms were seizures(n = 27), headache(n = 10), dizziness(n = 6), altered consciousness(n = 8), and psychologico-behavioral abnormalities(n = 14). Most patients had a good prognosis except 1 patient remained in a state of minimal consciousness during the follow-up.</p><p><strong>Conclusion: </strong>This research demonstrates some possible causes of RESLES. Patients with RESLES present with a variety of nonspecific symptoms and most of them had a good prognosis.</p><p><strong>Significance: </strong>These findings are groundbreaking to a deeper understanding of RESLES.</p>\",\"PeriodicalId\":19191,\"journal\":{\"name\":\"Neurological Sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurological Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10072-025-08554-4\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10072-025-08554-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Some novel causes and clinical characteristics of reversible splenial lesion syndrome- found in children.
Objective: To describe causes, clinical manifestations, imaging features and prognosis of reversible splenial lesion syndrome (RESLES) in children.
Methods: A total of 36 patients with RESLES hospitalized in Children's Hospital of Chongqing Medical University between January 1, 2017 and Mar 31, 2024 were included. The clinical features including the causes, clinical manifestations and prognosis were statistically analyzed.
Results: The patients' ages ranged from 16 to 170 months with a median age of 49 months. Of the 36 patients, 24 patients were RESLES type-1 (the lesions were limited to SCC) and 12 patients were RESLES type-2(the lesions spread to other parts of the corpus callosum, extensive brain white matter, or both). The participating causes included infection, chemotherapy, immunoglobulin A vasculitis, autoimmune glial fibrillary acidic protein astrocytopathy, hypertension and hypoparathyroidism. The common neurological symptoms were seizures(n = 27), headache(n = 10), dizziness(n = 6), altered consciousness(n = 8), and psychologico-behavioral abnormalities(n = 14). Most patients had a good prognosis except 1 patient remained in a state of minimal consciousness during the follow-up.
Conclusion: This research demonstrates some possible causes of RESLES. Patients with RESLES present with a variety of nonspecific symptoms and most of them had a good prognosis.
Significance: These findings are groundbreaking to a deeper understanding of RESLES.
期刊介绍：
Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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