Yujun He, Miao Zhou, Jie Tang, Yaling Zheng, Jianying Chen, Bowen Xing, Dan Li, Mengya Liang, Weiwei Tang, Xiaojun Li, Xiaoyi Wang
{"title":"下肢外周动脉疾病的全球、区域和国家负担:1990年至2021年的患病率、发病率、死亡和天数的系统分析,并预测到2036年的饮食风险因素。","authors":"Yujun He, Miao Zhou, Jie Tang, Yaling Zheng, Jianying Chen, Bowen Xing, Dan Li, Mengya Liang, Weiwei Tang, Xiaojun Li, Xiaoyi Wang","doi":"10.1186/s41043-025-01094-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This research aims to analyze the global, regional, and national burden of LE-PAD from 1990 to 2021 through the GBD 2021 database. We also assess the impact of dietary risk factors and use decomposition and frontier analyses to identify key drivers and disparities in disease burden.</p><p><strong>Methods: </strong>We used data from the GBD 2021 study (covering 204 countries and territories) to analyze LE-PAD-related prevalence, incidence, mortality, and DALYs, and conducted trend analysis and projections via joinpoint regression and autoregressive integrated moving average (ARIMA) models. Decomposition analysis evaluated the contributions of population growth, aging, and epidemiological changes, and frontier analysis identified countries with high LE-PAD rates relative to their SDI.</p><p><strong>Results: </strong>From 1990 to 2021, global LE-PAD prevalence and incidence rose significantly. Females had higher prevalence, and males under 75 had higher mortality. Dietary risk factors like high processed meat and low whole-grain intake were major contributors. Population growth drove the increased burden, somewhat mitigated by epidemiological changes. Frontier analysis showed country disparities, with some high-income countries having relatively high LE-PAD burden.</p><p><strong>Conclusion: </strong>The growing burden of LE-PAD demands targeted interventions, better healthcare infrastructure, and sustained research. Addressing modifiable risk factors, promoting healthy lifestyles, and conducting effective public health campaigns and education are crucial to reduce its impact.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":"44 1","pages":"351"},"PeriodicalIF":2.8000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Global, regional, and national burden of lower extremity peripheral arterial disease: a systematic analysis of prevalence, incidence, deaths, and dalys from 1990 to 2021 with projections and dietary risk factors to 2036.\",\"authors\":\"Yujun He, Miao Zhou, Jie Tang, Yaling Zheng, Jianying Chen, Bowen Xing, Dan Li, Mengya Liang, Weiwei Tang, Xiaojun Li, Xiaoyi Wang\",\"doi\":\"10.1186/s41043-025-01094-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This research aims to analyze the global, regional, and national burden of LE-PAD from 1990 to 2021 through the GBD 2021 database. We also assess the impact of dietary risk factors and use decomposition and frontier analyses to identify key drivers and disparities in disease burden.</p><p><strong>Methods: </strong>We used data from the GBD 2021 study (covering 204 countries and territories) to analyze LE-PAD-related prevalence, incidence, mortality, and DALYs, and conducted trend analysis and projections via joinpoint regression and autoregressive integrated moving average (ARIMA) models. Decomposition analysis evaluated the contributions of population growth, aging, and epidemiological changes, and frontier analysis identified countries with high LE-PAD rates relative to their SDI.</p><p><strong>Results: </strong>From 1990 to 2021, global LE-PAD prevalence and incidence rose significantly. Females had higher prevalence, and males under 75 had higher mortality. Dietary risk factors like high processed meat and low whole-grain intake were major contributors. Population growth drove the increased burden, somewhat mitigated by epidemiological changes. Frontier analysis showed country disparities, with some high-income countries having relatively high LE-PAD burden.</p><p><strong>Conclusion: </strong>The growing burden of LE-PAD demands targeted interventions, better healthcare infrastructure, and sustained research. Addressing modifiable risk factors, promoting healthy lifestyles, and conducting effective public health campaigns and education are crucial to reduce its impact.</p>\",\"PeriodicalId\":15969,\"journal\":{\"name\":\"Journal of Health, Population, and Nutrition\",\"volume\":\"44 1\",\"pages\":\"351\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Health, Population, and Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s41043-025-01094-9\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Health, Population, and Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s41043-025-01094-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Global, regional, and national burden of lower extremity peripheral arterial disease: a systematic analysis of prevalence, incidence, deaths, and dalys from 1990 to 2021 with projections and dietary risk factors to 2036.
Objective: This research aims to analyze the global, regional, and national burden of LE-PAD from 1990 to 2021 through the GBD 2021 database. We also assess the impact of dietary risk factors and use decomposition and frontier analyses to identify key drivers and disparities in disease burden.
Methods: We used data from the GBD 2021 study (covering 204 countries and territories) to analyze LE-PAD-related prevalence, incidence, mortality, and DALYs, and conducted trend analysis and projections via joinpoint regression and autoregressive integrated moving average (ARIMA) models. Decomposition analysis evaluated the contributions of population growth, aging, and epidemiological changes, and frontier analysis identified countries with high LE-PAD rates relative to their SDI.
Results: From 1990 to 2021, global LE-PAD prevalence and incidence rose significantly. Females had higher prevalence, and males under 75 had higher mortality. Dietary risk factors like high processed meat and low whole-grain intake were major contributors. Population growth drove the increased burden, somewhat mitigated by epidemiological changes. Frontier analysis showed country disparities, with some high-income countries having relatively high LE-PAD burden.
Conclusion: The growing burden of LE-PAD demands targeted interventions, better healthcare infrastructure, and sustained research. Addressing modifiable risk factors, promoting healthy lifestyles, and conducting effective public health campaigns and education are crucial to reduce its impact.
期刊介绍:
Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.