{"title":"改变生物活性玻璃微粒溶胶-凝胶合成过程中的pH值及其对结构和抗菌性能的影响。","authors":"Danielle L Perry, Anthony W Wren","doi":"10.1177/08853282251386622","DOIUrl":null,"url":null,"abstract":"<p><p>In sol-gel glass chemistry, the pH of the sol directly influences the rate of the hydrolysis and condensation reactions, leading to changes in the glass's structural properties and potentially altering its function as a biomaterial. This research used various acidic pH values, 2, 3, 3.65, 5, and 5.65, to create sol-gel bioactive glass with a 45SiO<sub>2</sub>-14.5NaO<sub>2</sub>-14.5CaO-6P<sub>2</sub>O<sub>5</sub>-10ZnO-5CuO-5CoO mol% composition. A pH of 2 allowed for increased surface area, 26.23 m<sup>2</sup>/g, and cumulative surface area of pores, 34.78 m<sup>2</sup>/g, compared to the other pH values used. Raman spectroscopy highlighted variances in the intensity of Q<sup>2</sup> and Q<sup>3</sup> species, with a pH of 2 and 3.65 having a higher intensity of Q<sup>3</sup> species. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) revealed that the concentration of Cu<sup>2+</sup> ions released from the glass network in simulated body fluid (SBF) was the highest after 1000 h of incubation for the pH 3.65 glass, 100 mg/L, which translated to the most significant inhibition of <i>E. coli</i> after 48 h of contact. Elemental, thermal, and structural analysis using energy dispersive X-ray spectroscopy, differential thermal analysis, Fourier-Transform Infrared Spectroscopy, and X-ray diffraction was also performed, with no discernible relationship found between changing the pH of the sol used to synthesize these glasses.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251386622"},"PeriodicalIF":2.5000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Altering the pH during sol-gel synthesis of bioactive glass particles and its effect on structural and antibacterial properties.\",\"authors\":\"Danielle L Perry, Anthony W Wren\",\"doi\":\"10.1177/08853282251386622\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In sol-gel glass chemistry, the pH of the sol directly influences the rate of the hydrolysis and condensation reactions, leading to changes in the glass's structural properties and potentially altering its function as a biomaterial. This research used various acidic pH values, 2, 3, 3.65, 5, and 5.65, to create sol-gel bioactive glass with a 45SiO<sub>2</sub>-14.5NaO<sub>2</sub>-14.5CaO-6P<sub>2</sub>O<sub>5</sub>-10ZnO-5CuO-5CoO mol% composition. A pH of 2 allowed for increased surface area, 26.23 m<sup>2</sup>/g, and cumulative surface area of pores, 34.78 m<sup>2</sup>/g, compared to the other pH values used. Raman spectroscopy highlighted variances in the intensity of Q<sup>2</sup> and Q<sup>3</sup> species, with a pH of 2 and 3.65 having a higher intensity of Q<sup>3</sup> species. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) revealed that the concentration of Cu<sup>2+</sup> ions released from the glass network in simulated body fluid (SBF) was the highest after 1000 h of incubation for the pH 3.65 glass, 100 mg/L, which translated to the most significant inhibition of <i>E. coli</i> after 48 h of contact. Elemental, thermal, and structural analysis using energy dispersive X-ray spectroscopy, differential thermal analysis, Fourier-Transform Infrared Spectroscopy, and X-ray diffraction was also performed, with no discernible relationship found between changing the pH of the sol used to synthesize these glasses.</p>\",\"PeriodicalId\":15138,\"journal\":{\"name\":\"Journal of Biomaterials Applications\",\"volume\":\" \",\"pages\":\"8853282251386622\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomaterials Applications\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/08853282251386622\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials Applications","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/08853282251386622","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Altering the pH during sol-gel synthesis of bioactive glass particles and its effect on structural and antibacterial properties.
In sol-gel glass chemistry, the pH of the sol directly influences the rate of the hydrolysis and condensation reactions, leading to changes in the glass's structural properties and potentially altering its function as a biomaterial. This research used various acidic pH values, 2, 3, 3.65, 5, and 5.65, to create sol-gel bioactive glass with a 45SiO2-14.5NaO2-14.5CaO-6P2O5-10ZnO-5CuO-5CoO mol% composition. A pH of 2 allowed for increased surface area, 26.23 m2/g, and cumulative surface area of pores, 34.78 m2/g, compared to the other pH values used. Raman spectroscopy highlighted variances in the intensity of Q2 and Q3 species, with a pH of 2 and 3.65 having a higher intensity of Q3 species. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) revealed that the concentration of Cu2+ ions released from the glass network in simulated body fluid (SBF) was the highest after 1000 h of incubation for the pH 3.65 glass, 100 mg/L, which translated to the most significant inhibition of E. coli after 48 h of contact. Elemental, thermal, and structural analysis using energy dispersive X-ray spectroscopy, differential thermal analysis, Fourier-Transform Infrared Spectroscopy, and X-ray diffraction was also performed, with no discernible relationship found between changing the pH of the sol used to synthesize these glasses.
期刊介绍:
The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials.
Peer-reviewed articles by biomedical specialists from around the world cover:
New developments in biomaterials, R&D, properties and performance, evaluation and applications
Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices
Current findings in biological compatibility/incompatibility of biomaterials
The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use.
The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.