改变生物活性玻璃微粒溶胶-凝胶合成过程中的pH值及其对结构和抗菌性能的影响。

IF 2.5 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Danielle L Perry, Anthony W Wren
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引用次数: 0

摘要

在溶胶-凝胶玻璃化学中,溶胶的pH值直接影响水解和缩合反应的速率,导致玻璃结构性质的变化,并可能改变其作为生物材料的功能。本研究在不同的酸性pH值(2、3、3.65、5和5.65)下,制备了45SiO2-14.5NaO2-14.5CaO-6P2O5-10ZnO-5CuO-5CoO摩尔百分比组成的溶胶-凝胶生物活性玻璃。与使用的其他pH值相比,pH值为2可以增加表面积26.23 m2/g,孔隙累积表面积34.78 m2/g。拉曼光谱显示Q2和Q3的强度存在差异,pH值为2和3.65时,Q3的强度更高。电感耦合等离子体发射光谱(ICP-OES)结果表明,pH为3.65,100 mg/L的模拟体液(SBF)中,培养1000 h后,玻璃网络释放的Cu2+离子浓度最高,接触48 h后对大肠杆菌的抑制作用最显著。使用能量色散x射线光谱、差热分析、傅里叶变换红外光谱和x射线衍射进行元素、热和结构分析,也进行了分析,没有发现改变用于合成这些玻璃的溶胶的pH之间的明显关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altering the pH during sol-gel synthesis of bioactive glass particles and its effect on structural and antibacterial properties.

In sol-gel glass chemistry, the pH of the sol directly influences the rate of the hydrolysis and condensation reactions, leading to changes in the glass's structural properties and potentially altering its function as a biomaterial. This research used various acidic pH values, 2, 3, 3.65, 5, and 5.65, to create sol-gel bioactive glass with a 45SiO2-14.5NaO2-14.5CaO-6P2O5-10ZnO-5CuO-5CoO mol% composition. A pH of 2 allowed for increased surface area, 26.23 m2/g, and cumulative surface area of pores, 34.78 m2/g, compared to the other pH values used. Raman spectroscopy highlighted variances in the intensity of Q2 and Q3 species, with a pH of 2 and 3.65 having a higher intensity of Q3 species. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) revealed that the concentration of Cu2+ ions released from the glass network in simulated body fluid (SBF) was the highest after 1000 h of incubation for the pH 3.65 glass, 100 mg/L, which translated to the most significant inhibition of E. coli after 48 h of contact. Elemental, thermal, and structural analysis using energy dispersive X-ray spectroscopy, differential thermal analysis, Fourier-Transform Infrared Spectroscopy, and X-ray diffraction was also performed, with no discernible relationship found between changing the pH of the sol used to synthesize these glasses.

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来源期刊
Journal of Biomaterials Applications
Journal of Biomaterials Applications 工程技术-材料科学:生物材料
CiteScore
5.10
自引率
3.40%
发文量
144
审稿时长
1.5 months
期刊介绍: The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.
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