Azadeh Saberi, Amir Moeintaghavi, Hossein Bagheri, Sahar Mollazadeh Beidokhti, Mohammad Jalili Nik
{"title":"新型可注射硅酸三钙复合骨水泥,内置抗菌保护。","authors":"Azadeh Saberi, Amir Moeintaghavi, Hossein Bagheri, Sahar Mollazadeh Beidokhti, Mohammad Jalili Nik","doi":"10.1177/08853282251379731","DOIUrl":null,"url":null,"abstract":"<p><p>This investigation examines the influence of calcium sulfate (CaS) and modified nano-hydroxyapatite (mHA) additions on the physicochemical properties, microstructural development, apatite-forming potential, and antibacterial properties of bioactive tricalcium silicate (C<sub>3</sub>S) cement. Although C<sub>3</sub>S cements exhibit inherent antibacterial properties, their efficacy in treating infected bone defects requires enhancement. The release kinetics of vancomycin (VANCO), an antibiotic, and the modified cements' antibacterial efficacy were systematically evaluated. The findings revealed a notable decrease in setting time from 363 to 264 min upon the integration of CaS. The composite cements demonstrated flow properties and injectability that met standard requirements, exceeding 75% at both 2 and 5 min. The modified cements noted Improved compressive strength compared to their unmodified counterparts. Furthermore, the cements promoted the formation of apatite on their surfaces when immersed in phosphate-buffered saline (PBS). Antibacterial evaluations established that VANCO released from the composites effectively impeded bacterial proliferation. These findings suggest that C<sub>3</sub>S cement enhanced with CaS and mHA exhibits superior physicochemical characteristics and bioactivity, thereby establishing it as a promising candidate for cutting-edge bone repair materials.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251379731"},"PeriodicalIF":2.5000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel injectable tricalcium silicate composite bone cement with built-in antibacterial protection.\",\"authors\":\"Azadeh Saberi, Amir Moeintaghavi, Hossein Bagheri, Sahar Mollazadeh Beidokhti, Mohammad Jalili Nik\",\"doi\":\"10.1177/08853282251379731\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This investigation examines the influence of calcium sulfate (CaS) and modified nano-hydroxyapatite (mHA) additions on the physicochemical properties, microstructural development, apatite-forming potential, and antibacterial properties of bioactive tricalcium silicate (C<sub>3</sub>S) cement. Although C<sub>3</sub>S cements exhibit inherent antibacterial properties, their efficacy in treating infected bone defects requires enhancement. The release kinetics of vancomycin (VANCO), an antibiotic, and the modified cements' antibacterial efficacy were systematically evaluated. The findings revealed a notable decrease in setting time from 363 to 264 min upon the integration of CaS. The composite cements demonstrated flow properties and injectability that met standard requirements, exceeding 75% at both 2 and 5 min. The modified cements noted Improved compressive strength compared to their unmodified counterparts. Furthermore, the cements promoted the formation of apatite on their surfaces when immersed in phosphate-buffered saline (PBS). Antibacterial evaluations established that VANCO released from the composites effectively impeded bacterial proliferation. These findings suggest that C<sub>3</sub>S cement enhanced with CaS and mHA exhibits superior physicochemical characteristics and bioactivity, thereby establishing it as a promising candidate for cutting-edge bone repair materials.</p>\",\"PeriodicalId\":15138,\"journal\":{\"name\":\"Journal of Biomaterials Applications\",\"volume\":\" \",\"pages\":\"8853282251379731\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomaterials Applications\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/08853282251379731\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials Applications","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/08853282251379731","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Novel injectable tricalcium silicate composite bone cement with built-in antibacterial protection.
This investigation examines the influence of calcium sulfate (CaS) and modified nano-hydroxyapatite (mHA) additions on the physicochemical properties, microstructural development, apatite-forming potential, and antibacterial properties of bioactive tricalcium silicate (C3S) cement. Although C3S cements exhibit inherent antibacterial properties, their efficacy in treating infected bone defects requires enhancement. The release kinetics of vancomycin (VANCO), an antibiotic, and the modified cements' antibacterial efficacy were systematically evaluated. The findings revealed a notable decrease in setting time from 363 to 264 min upon the integration of CaS. The composite cements demonstrated flow properties and injectability that met standard requirements, exceeding 75% at both 2 and 5 min. The modified cements noted Improved compressive strength compared to their unmodified counterparts. Furthermore, the cements promoted the formation of apatite on their surfaces when immersed in phosphate-buffered saline (PBS). Antibacterial evaluations established that VANCO released from the composites effectively impeded bacterial proliferation. These findings suggest that C3S cement enhanced with CaS and mHA exhibits superior physicochemical characteristics and bioactivity, thereby establishing it as a promising candidate for cutting-edge bone repair materials.
期刊介绍:
The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials.
Peer-reviewed articles by biomedical specialists from around the world cover:
New developments in biomaterials, R&D, properties and performance, evaluation and applications
Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices
Current findings in biological compatibility/incompatibility of biomaterials
The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use.
The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.