口服胰岛素控释纳米药物的研究进展。

IF 2.5 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Ayana Kannaghut Puthukudi, Kaladhar Kamalasanan, Prajitha Prabhakaran Ganga, Harika Sapa, Shona Sara Shaji, Sreejith Thrivikraman, Althaf Umar, Sherin Ann, Shine Sadasivan, Praveen Vp, Mishra Narayan Chandra, Hani Harb, Manish Kumar Jeengar
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引用次数: 0

摘要

频繁注射胰岛素仍然是糖尿病患者调节血糖水平的主要方法;然而,患者的依从性往往很差。由于其非侵入性,口服胰岛素,探索纳米药物策略,被认为是一种非常理想的替代方案,作为一种负担得起的和可获得的药物。然而,肠道物理屏障和恶劣的胃肠道环境是胰岛素达到最佳药理生物利用度的主要障碍。使用胶体纳米载体,包括聚合物纳米颗粒、磷脂囊泡和脂基纳米颗粒,可以改善胰岛素的稳定性、生物利用度和整个胃肠道的靶向给药。这些纳米载体模拟胰岛素的生理性分泌,并通过屏蔽胰岛素的酶降解、促进控制释放和增强肠道粘膜的吸收来改善胰岛素的药代动力学。关键参数,如颗粒大小,表面电荷,zeta电位,和聚合物-粘蛋白相互作用检查有关他们对上皮运输和酶保护的影响。讨论了聚乙二醇化、壳聚糖功能化和胆盐掺入等策略,重点讨论了它们的界面工程潜力。此外,新的策略,如葡萄糖反应配方,细胞穿透肽和酶抑制剂,以及创新的设备,如微针胶囊和SOMA系统,已经被探索来提高口服胰岛素的疗效。然而,这可能对翻译本身没有帮助。另一个决定性因素将是与不同路径的结合。未来的前景和创新的方法,以提高纳米驱动系统的治疗潜力,口服胰岛素给药也在这篇综述中讨论作为一个负担得起的和可获得的药物策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Towards oral insulin-controlled release nanomedicine: A review.

Frequent insulin injections remain the primary method for regulating blood glucose levels in individuals with diabetes mellitus; however, patient compliance is often poor. Due to its non-invasive nature, oral insulin delivery, exploring nanomedicine strategies, is considered a highly desirable alternative as an affordable and accessible medicine. However, the physical intestinal barriers and the harsh gastrointestinal environment provide major obstacles to reaching the best possible pharmacological bioavailability of insulin. Insulin's stability, bioavailability, and targeted administration throughout the GI tract can be improved using colloidal nanocarriers, including polymeric nanoparticles, phospholipid vesicles, and lipid-based nanoparticles. These nanocarriers mimic the physiological insulin secretion and improve the pharmacokinetics of insulin by shielding it from enzymatic degradation, facilitating controlled release, and enhancing absorption across the intestinal mucosa. Key parameters such as particle size, surface charge, zeta potential, and polymer-mucin interactions are examined concerning their effects on epithelial transport and enzymatic protection. Strategies such as PEGylation, chitosan functionalization, and bile salt incorporation are discussed with an emphasis on their interfacial engineering potential. Additionally, novel strategies such as glucose-responsive formulations, cell-penetrating peptides, and enzyme inhibitors, and innovative devices like microneedle capsules and SOMA systems have been explored to enhance oral insulin efficacy. This might not, however, be helpful for translation on its own. Another deciding aspect will be the combination of that with distinct pathways. Future perspectives and innovative approaches to enhance the therapeutic potential of nano-driven systems for oral insulin administration are also discussed in this review as an affordable and accessible medicine strategy.

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来源期刊
Journal of Biomaterials Applications
Journal of Biomaterials Applications 工程技术-材料科学:生物材料
CiteScore
5.10
自引率
3.40%
发文量
144
审稿时长
1.5 months
期刊介绍: The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.
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