揭示机制联系:微量营养素的富集如何塑造大脑功能和认知健康。

IF 3.9 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Frontiers in Molecular Biosciences Pub Date : 2025-09-23 eCollection Date: 2025-01-01 DOI:10.3389/fmolb.2025.1623547
Siddhartha Das, Pradipta Banerjee, Sudipta Jana, Hemanshu Mondal
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引用次数: 0

摘要

矿物质、维生素和微量元素是心理健康和大脑功能所必需的微量营养素。严重的疾病可能是由于它们的缺乏,或者相反,由于它们的过量。最近的研究表明,某些神经系统疾病的发病机制可能与微量营养素水平的长期升高有关。生理功能,如能量代谢,神经递质合成和抗氧化防御,由这些重要的营养物质调节,是最佳的神经元活动所必需的。根据一项新的研究,无论是通过饮食还是补充剂,微量营养素的富集都会对认知功能、神经可塑性和大脑发育产生重大影响。认知能力下降、记忆力减退和注意力问题都与缺乏必要的微量营养素有关,这些微量营养素包括维生素B12、铁、锌和omega-3脂肪酸。量身定制的微量营养素疗法在减少与年龄相关的认知衰退和增强健康个体和高危人群的心理功能方面显示出了希望。这篇文章强调了越来越多的研究将微量营养素状况与认知健康联系起来。它还强调了保持均衡饮食和遵循适当的补充实践以优化大脑功能的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unveiling the mechanistic nexus: how micronutrient enrichment shapes brain function, and cognitive health.

Minerals, vitamins, and trace elements are examples of micronutrients essential for psychological wellbeing and brain function. Severe disorders may result from their deficiency or, conversely, from an excess of them. Recent studies have indicated that the etiopathogenesis of certain neurological disorders may involve chronically elevated micronutrient levels. Physiological functions, such as energy metabolism, neurotransmitter synthesis, and antioxidant defence, are regulated by these vital nutrients and are essential for optimal neuronal activity. According to new research, micronutrient enrichment, whether through diet or supplements, can have a significant impact on cognitive function, neuroplasticity, and brain development. Cognitive decline, memory loss, and attention problems are linked to deficiencies in essential micronutrients, including vitamin B12, iron, zinc, and omega-3 fatty acids. Tailored micronutrient therapies have shown promise in reducing age-related cognitive decline and enhancing mental function in both healthy individuals and those at greater risk. This manuscript emphasizes the growing research linking micronutrient status to cognitive health. It also highlights the importance of maintaining a balanced diet and following appropriate supplementation practices to optimize brain function throughout life.

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来源期刊
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
7.20
自引率
4.00%
发文量
1361
审稿时长
14 weeks
期刊介绍: Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.
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