Aqsa Aizaz, Muhammad Haseeb Nawaz, Muhammad Sameet Ismat, Md Abdur Rashid, Muhammad Atiq Ur Rehman
{"title":"蜂胶增强海藻酸钠水凝胶，富含铜掺杂的介孔生物活性玻璃纳米颗粒，用于高级烧伤护理应用。","authors":"Aqsa Aizaz, Muhammad Haseeb Nawaz, Muhammad Sameet Ismat, Md Abdur Rashid, Muhammad Atiq Ur Rehman","doi":"10.1007/s10529-025-03662-9","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic wounds, with prolonged healing time, remain a formidable challenge due to lack of angiogenesis, antimicrobial effect, and biocompatibility of conventional wound dressings. The current study focuses on developing novel copper-doped mesoporous bioactive glass nanoparticles (Cu-MBGNs) doped with Propolis/ Sodium Alginate (ALG) based hydrogel to promote angiogenesis, tissue regeneration, biocompatibility, and antimicrobial efficacy for advanced wound healing applications. Hydrogel was synthesized using a solution-casting method. It was characterized using material and biological characterization techniques. Scanning electron microscopy (SEM) displayed an interconnected porous network with dispersed Cu-MBGNs facilitating hydrogel swelling/deswelling and degradation behavior (75%). Fourier Transform Infrared Spectroscopy (FTIR) confirmed crosslinking between propolis and ALG via hydrogen bonding. Hydrogel exhibited an antimicrobial effect against Escherichia coli and Staphylococcus gallinarum. Cu<sup>+2</sup> promoted vasculogenesis by modulating vascular endothelial growth factor release and cytocompatibility. These results suggest that Propolis/ALG/Cu-MBGNs hydrogel offers cost-effective and sustainable solution for enhanced wound healing.</p>","PeriodicalId":8929,"journal":{"name":"Biotechnology Letters","volume":"47 5","pages":"121"},"PeriodicalIF":2.1000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Propolis enhanced sodium alginate hydrogel enriched with copper doped mesoporous bioactive glass nanoparticles for advanced burn care applications.\",\"authors\":\"Aqsa Aizaz, Muhammad Haseeb Nawaz, Muhammad Sameet Ismat, Md Abdur Rashid, Muhammad Atiq Ur Rehman\",\"doi\":\"10.1007/s10529-025-03662-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Chronic wounds, with prolonged healing time, remain a formidable challenge due to lack of angiogenesis, antimicrobial effect, and biocompatibility of conventional wound dressings. The current study focuses on developing novel copper-doped mesoporous bioactive glass nanoparticles (Cu-MBGNs) doped with Propolis/ Sodium Alginate (ALG) based hydrogel to promote angiogenesis, tissue regeneration, biocompatibility, and antimicrobial efficacy for advanced wound healing applications. Hydrogel was synthesized using a solution-casting method. It was characterized using material and biological characterization techniques. Scanning electron microscopy (SEM) displayed an interconnected porous network with dispersed Cu-MBGNs facilitating hydrogel swelling/deswelling and degradation behavior (75%). Fourier Transform Infrared Spectroscopy (FTIR) confirmed crosslinking between propolis and ALG via hydrogen bonding. Hydrogel exhibited an antimicrobial effect against Escherichia coli and Staphylococcus gallinarum. Cu<sup>+2</sup> promoted vasculogenesis by modulating vascular endothelial growth factor release and cytocompatibility. These results suggest that Propolis/ALG/Cu-MBGNs hydrogel offers cost-effective and sustainable solution for enhanced wound healing.</p>\",\"PeriodicalId\":8929,\"journal\":{\"name\":\"Biotechnology Letters\",\"volume\":\"47 5\",\"pages\":\"121\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biotechnology Letters\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1007/s10529-025-03662-9\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnology Letters","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s10529-025-03662-9","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Propolis enhanced sodium alginate hydrogel enriched with copper doped mesoporous bioactive glass nanoparticles for advanced burn care applications.
Chronic wounds, with prolonged healing time, remain a formidable challenge due to lack of angiogenesis, antimicrobial effect, and biocompatibility of conventional wound dressings. The current study focuses on developing novel copper-doped mesoporous bioactive glass nanoparticles (Cu-MBGNs) doped with Propolis/ Sodium Alginate (ALG) based hydrogel to promote angiogenesis, tissue regeneration, biocompatibility, and antimicrobial efficacy for advanced wound healing applications. Hydrogel was synthesized using a solution-casting method. It was characterized using material and biological characterization techniques. Scanning electron microscopy (SEM) displayed an interconnected porous network with dispersed Cu-MBGNs facilitating hydrogel swelling/deswelling and degradation behavior (75%). Fourier Transform Infrared Spectroscopy (FTIR) confirmed crosslinking between propolis and ALG via hydrogen bonding. Hydrogel exhibited an antimicrobial effect against Escherichia coli and Staphylococcus gallinarum. Cu+2 promoted vasculogenesis by modulating vascular endothelial growth factor release and cytocompatibility. These results suggest that Propolis/ALG/Cu-MBGNs hydrogel offers cost-effective and sustainable solution for enhanced wound healing.
期刊介绍：
Biotechnology Letters is the world’s leading rapid-publication primary journal dedicated to biotechnology as a whole – that is to topics relating to actual or potential applications of biological reactions affected by microbial, plant or animal cells and biocatalysts derived from them.
All relevant aspects of molecular biology, genetics and cell biochemistry, of process and reactor design, of pre- and post-treatment steps, and of manufacturing or service operations are therefore included.
Contributions from industrial and academic laboratories are equally welcome. We also welcome contributions covering biotechnological aspects of regenerative medicine and biomaterials and also cancer biotechnology. Criteria for the acceptance of papers relate to our aim of publishing useful and informative results that will be of value to other workers in related fields.
The emphasis is very much on novelty and immediacy in order to justify rapid publication of authors’ results. It should be noted, however, that we do not normally publish papers (but this is not absolute) that deal with unidentified consortia of microorganisms (e.g. as in activated sludge) as these results may not be easily reproducible in other laboratories.
Papers describing the isolation and identification of microorganisms are not regarded as appropriate but such information can be appended as supporting information to a paper. Papers dealing with simple process development are usually considered to lack sufficient novelty or interest to warrant publication.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
