Study the Changing Trends of Age at Diagnosis of Breast Carcinoma in Correlation with Polycystic Ovarian Syndrome, Obesity, and Nutritional Status.

Background: Hormonal factors, metabolic conditions such as polycystic ovary syndrome (PCOS), obesity, and nutritional deficiencies, influence the risk and prognosis of breast cancer risk. Understanding the interplay among these factors helps in identifying potential targets for prevention and treatment strategies.

Aim: The study aims to examine the shifting patterns in the age of breast cancer diagnosis and explore their associations with PCOS, obesity, and nutritional status.

Methods: The prospective observational study included patients with histopathologically confirmed breast carcinoma. Detailed demographic and clinical data, including age at diagnosis, parity, menopausal status, and body mass index (used to classify obesity) were collected. Symptoms suggestive of PCOS and nutritional deficiencies (Vitamin D, iron, and iodine) were evaluated using laboratory and radiological findings. Histopathological findings and hormone receptor status were also noted.

Results: Most women diagnosed with breast carcinoma were between 29 and 50 years (46.7%), postmenopausal (53.3%), overweight (58.7%), had PCOS (20.0%), and Vitamin D deficiency (68.0%). Invasive ductal carcinoma (90.7%) was the most common histopathological subtype, and most tumors were estrogen receptor (ER)-positive, especially ER + PR + Her2- (41.3%). None of the factors - PCOS, obesity, and nutritional status - were associated with histopathological subtypes (P > 0.05). However, PCOS was more common in ER-positive cases than ER-negative cases (P = 0.04), whereas obesity and nutritional status showed no association with hormone receptor status (P > 0.05).

Conclusion: High prevalence of breast carcinoma cases in women aged 31-50 years highlights shifting trend in its diagnosis. Nearly 80% of breast cancer patients had PCOS, suggesting its influence on tumor biology. Notable prevalence of nutritional deficiency (Vitamin D, serum iron, serum iodine, and folic acid deficiency) warrants further investigation into their role in breast cancer pathogenesis.