Bartosz Klebowski, Adrianna Gałuszka-Bulaga, Marcin Strawski, Jan Jakub Kęsik, Jarek Baran, Joanna Depciuch
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Effect of the porosity of the palladium shell in Au-core Pd-shell bimetallic nanoparticles for the radiosensitizing properties in simulated anticancer proton radiotherapy.
The combination of radiotherapy and metallic nanoparticles (NPs) turns out to be a promising option for cancer treatment. Currently, proton radiotherapy (PRT) is becoming more and more popular. Compared to classic X-ray radiotherapy, PRT is characterized by similar treatment effectiveness while minimizing off-target effect. The purpose of this study was to synthesize and evaluate two types of bimetallic gold-palladium nanoparticles (AuPd NPs), that differ in the porosity of the palladium shell (non-porous AuPd CSs - core-shells and porous AuPd NRs - nanoraspberries), as radiosensitizers to improve the efficiency of proton irradiation. Importantly, both types of crystalline AuPd NPs had a similar shape (spherical) and size (⁓ 20 nm). The results of in vitro cell viability tests indicated similar cytotoxicity of both types of AuPd NPs towards selected cancer cell lines, as well as promising radiosensitizing potential in simulated PRT, especially for porous AuPd NRs. Moreover, holotomographic microscopy analysis showed that AuPd NPs at a low concentration of 75 μg/ml cause in culture detachment of low-aggressive SW480 colon cancer cells, but do not affect growth of aggressive HCT116 cancer cells and normal CRL-1790 epithelial cells in vitro. These results can open new perspectives on the further applications of NPs as radiosensitizers.
期刊介绍：
Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields.
Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication.
The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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