钴-salen配合物/有机光氧化还原-协同催化胺酮选择性氧化甲酰化。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-09 DOI:10.1039/d5cc03796d

Yaolian Shi, Yuchen Gong, Ganpeng Li, Xiao-Jing Zhao, Yonghui He

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引用次数: 0

摘要

在温和的条件下，通过钴-salen/光氧化还原-协同作用，对胺酮进行选择性氧化以实现甲酰化，从而获得产率高的甲酰化产物。这种光化学合成策略不需要使用过氧化物作为氧化剂，因此与更广泛的含氧化敏感基团的底物兼容。研究表明，含[CoIII]络合物对胺酮中n -甲基的选择性氧化起着至关重要的作用。

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Cobalt-salen complexes/organic photoredox-cocatalyzed selective oxidative formylation of enaminones.

A selective oxidation of enaminones to achieve formylation via cobalt-salen/photoredox-cocatalyzed synergy was developed, providing the corresponding formylation products in good yields under mild conditions. This photochemical synthetic strategy does not need to use peroxide as an oxidant, and hence is compatible with a wider range of oxidation-sensitive-group-containing substrates. Investigations indicated that the selective oxidation of the N-methyl group in enaminones by the [Co^III]-containing complex plays a vital role.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.