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通过人工智能引导的活页夹设计增强主要编辑

IF 32.1 1区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS
Nature Methods Pub Date : 2025-10-09 DOI:10.1038/s41592-025-02872-3
Lei Tang
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引用次数: 0

摘要

人工智能设计的结合物可以通过抑制DNA错配修复途径来提高启动编辑性能。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Enhancing prime editing via AI-guided binder design

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Enhancing prime editing via AI-guided binder design
AI-designed binders can enhance prime editing performance by inhibiting the DNA mismatch repair pathway.
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来源期刊
Nature Methods
Nature Methods 生物-生化研究方法
CiteScore
58.70
自引率
1.70%
发文量
326
审稿时长
1 months
期刊介绍： Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.
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