碳点纳米杂化物用于肿瘤微环境激活的癌症治疗

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews Pub Date : 2025-10-08 DOI:10.1016/j.ccr.2025.217236

Wubshet Mekonnen Girma , Shewaye Lakew Mekuria , Gangaraju Gedda , Xiangyang Shi , Yoo-Jin Park , Myung-Geol Pang

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引用次数: 0

摘要

复杂的肿瘤微环境和肿瘤的自我保护限制了抗癌药物的疗效，阻碍了临床转化。设计集诊断和治疗于一体的智能纳米药物是推进癌症治疗的关键。碳点（cd）具有荧光可调和多种表面化学性质，已被用于诊断和治疗。这些特性使得基于cd的纳米杂交体能够提供精确的、图像引导的肿瘤治疗。本文综述了cd的发展历史、基于cd的纳米杂化物的构建及其在肿瘤微环境激活、图像引导协同肿瘤治疗中的应用。最后，我们讨论了未来的研究方向和临床翻译面临的挑战。我们的目标是为精确治疗肿瘤提供基于cd的纳米杂交体的合理设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Carbon dot-based nanohybrids for tumor microenvironment-activated cancer theranostics

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Carbon dot-based nanohybrids for tumor microenvironment-activated cancer theranostics

The complex tumor microenvironment and tumor self-protection limit the efficacy of anticancer drugs, impeding clinical translation. Designing intelligent nanomedicines that integrate diagnosis and therapy is pivotal for advancing cancer treatment. Carbon dots (CDs), with tunable fluorescence and versatile surface chemistry, have been used in diagnosis and therapy. These properties enable CD-based nanohybrids to deliver precise, image-guided tumor therapy. This review summarizes the history of CDs, the construction of CD-based nanohybrids, and their applications in tumor microenvironment–activated, image-guided cooperative tumor therapies. Finally, we discuss future research directions and clinical translation challenges. We aim to inform the rational design of CD-based nanohybrids for precise tumor treatment.

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.