{"title":"每小时暴露于环境空气污染物与急性主动脉夹层风险：来自162个中国城市的证据","authors":"Zhenyu Liu, Shuangyue Qian, Kai Ren, Ruxing Wan, Ling Tang, Xiangyu Chang","doi":"10.1097/JOM.0000000000003574","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between hourly spikes in air pollutant exposure and the risk of acute aortic dissection (AAD) onset.</p><p><strong>Methods: </strong>This time-stratified case-crossover study analyzed a national Chinese registry of 3,125 AAD cases across 162 cities. Piecewise conditional logistic regression and distributed lag nonlinear models were used to estimate relative risks (RRs) and 95% confidence intervals.</p><p><strong>Results: </strong>Increases in PM10 (RR = 1.019 per 10 μg/m3) and CO (RR = 1.184 per 1 mg/m3) were associated with higher AAD risk. Exposure above thresholds yielded increased risks for PM2.5 > 200 μg/m3 (RR = 1.074 per 10 μg/m3) and NO2 > 100 μg/m3 (RR = 1.065 per μg/m3). Effects showed lagged patterns for CO and PM10. Males, older adults, hypertensive patients, smokers, and overweight individuals showed greater susceptibility.</p><p><strong>Conclusions: </strong>This study provides the first evidence that hourly air pollution spikes significantly increase AAD risk, supporting targeted public health measures.</p>","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hourly exposure to ambient air pollutants and risk of acute aortic dissection: Evidence from 162 Chinese cities.\",\"authors\":\"Zhenyu Liu, Shuangyue Qian, Kai Ren, Ruxing Wan, Ling Tang, Xiangyu Chang\",\"doi\":\"10.1097/JOM.0000000000003574\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To examine the association between hourly spikes in air pollutant exposure and the risk of acute aortic dissection (AAD) onset.</p><p><strong>Methods: </strong>This time-stratified case-crossover study analyzed a national Chinese registry of 3,125 AAD cases across 162 cities. Piecewise conditional logistic regression and distributed lag nonlinear models were used to estimate relative risks (RRs) and 95% confidence intervals.</p><p><strong>Results: </strong>Increases in PM10 (RR = 1.019 per 10 μg/m3) and CO (RR = 1.184 per 1 mg/m3) were associated with higher AAD risk. Exposure above thresholds yielded increased risks for PM2.5 > 200 μg/m3 (RR = 1.074 per 10 μg/m3) and NO2 > 100 μg/m3 (RR = 1.065 per μg/m3). Effects showed lagged patterns for CO and PM10. Males, older adults, hypertensive patients, smokers, and overweight individuals showed greater susceptibility.</p><p><strong>Conclusions: </strong>This study provides the first evidence that hourly air pollution spikes significantly increase AAD risk, supporting targeted public health measures.</p>\",\"PeriodicalId\":94100,\"journal\":{\"name\":\"Journal of occupational and environmental medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of occupational and environmental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/JOM.0000000000003574\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of occupational and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/JOM.0000000000003574","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hourly exposure to ambient air pollutants and risk of acute aortic dissection: Evidence from 162 Chinese cities.
Objective: To examine the association between hourly spikes in air pollutant exposure and the risk of acute aortic dissection (AAD) onset.
Methods: This time-stratified case-crossover study analyzed a national Chinese registry of 3,125 AAD cases across 162 cities. Piecewise conditional logistic regression and distributed lag nonlinear models were used to estimate relative risks (RRs) and 95% confidence intervals.
Results: Increases in PM10 (RR = 1.019 per 10 μg/m3) and CO (RR = 1.184 per 1 mg/m3) were associated with higher AAD risk. Exposure above thresholds yielded increased risks for PM2.5 > 200 μg/m3 (RR = 1.074 per 10 μg/m3) and NO2 > 100 μg/m3 (RR = 1.065 per μg/m3). Effects showed lagged patterns for CO and PM10. Males, older adults, hypertensive patients, smokers, and overweight individuals showed greater susceptibility.
Conclusions: This study provides the first evidence that hourly air pollution spikes significantly increase AAD risk, supporting targeted public health measures.
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