{"title":"弥漫性半球胶质瘤，H3 g34突变体，单中心经验和组织病理学分析。","authors":"Faizan Amer, Usman Hassan, Sajid Mushtaq, Asif Loya, Mudassar Hussain, Hina Maqbool","doi":"10.1007/s00428-025-04280-6","DOIUrl":null,"url":null,"abstract":"<p><p>Diffuse hemispheric glioma, H3 G34-mutant, is a rare, recently categorized, high-grade, infiltrative glioma. It usually occurs in the cerebral hemispheres of adolescents and young adults. Mutations in the H3-3A gene play a key oncogenic role in the pathogenesis of this entity, with missense mutations caused by amino acid substitutions at p.G35 (G34) position being the most common. The tumor has a broad histological spectrum, a distinct immunoprofile, and a dismal prognosis. Only a few studies have provided a detailed histopathological analysis of this tumor, and to the best of our knowledge, no study has been published on this tumor within the Pakistani population. The aim of this study is to provide an account of our experience with this tumor within the Pakistani population. Here, we provide a retrospective analysis of 13 cases diagnosed at our hospital, highlighting the extremely varied morphology we encountered, along with their complete immunohistochemical workup.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis.\",\"authors\":\"Faizan Amer, Usman Hassan, Sajid Mushtaq, Asif Loya, Mudassar Hussain, Hina Maqbool\",\"doi\":\"10.1007/s00428-025-04280-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Diffuse hemispheric glioma, H3 G34-mutant, is a rare, recently categorized, high-grade, infiltrative glioma. It usually occurs in the cerebral hemispheres of adolescents and young adults. Mutations in the H3-3A gene play a key oncogenic role in the pathogenesis of this entity, with missense mutations caused by amino acid substitutions at p.G35 (G34) position being the most common. The tumor has a broad histological spectrum, a distinct immunoprofile, and a dismal prognosis. Only a few studies have provided a detailed histopathological analysis of this tumor, and to the best of our knowledge, no study has been published on this tumor within the Pakistani population. The aim of this study is to provide an account of our experience with this tumor within the Pakistani population. Here, we provide a retrospective analysis of 13 cases diagnosed at our hospital, highlighting the extremely varied morphology we encountered, along with their complete immunohistochemical workup.</p>\",\"PeriodicalId\":23514,\"journal\":{\"name\":\"Virchows Archiv\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virchows Archiv\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00428-025-04280-6\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virchows Archiv","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00428-025-04280-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis.
Diffuse hemispheric glioma, H3 G34-mutant, is a rare, recently categorized, high-grade, infiltrative glioma. It usually occurs in the cerebral hemispheres of adolescents and young adults. Mutations in the H3-3A gene play a key oncogenic role in the pathogenesis of this entity, with missense mutations caused by amino acid substitutions at p.G35 (G34) position being the most common. The tumor has a broad histological spectrum, a distinct immunoprofile, and a dismal prognosis. Only a few studies have provided a detailed histopathological analysis of this tumor, and to the best of our knowledge, no study has been published on this tumor within the Pakistani population. The aim of this study is to provide an account of our experience with this tumor within the Pakistani population. Here, we provide a retrospective analysis of 13 cases diagnosed at our hospital, highlighting the extremely varied morphology we encountered, along with their complete immunohistochemical workup.
期刊介绍：
Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.
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