{"title":"有氧和阻力训练联合功能电刺激（FES）对缺血性卒中后男性炎症、止血和脂质指标的影响：一项随机对照试验","authors":"Morteza Mostaghimi, Ali Heidarianpour","doi":"10.1080/10749357.2025.2566140","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke is linked to endothelial dysfunction, inflammation, and disrupted hemostasis, particularly involving Von Willebrand factor (vWF), ADAMTS13, and pro-inflammatory cytokines. While functional electrical stimulation (FES) and exercise are used in stroke rehabilitation, the combined effects on inflammation and hemostatic markers remain unclear.</p><p><strong>Objectives: </strong>This study aimed to evaluate and compare the effects of aerobic-FES (A-ES), resistance-FES (R-ES), and FES alone on vWF, ADAMTS13 activity, interleukin-6 (IL-6), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in men with ischemic stroke.</p><p><strong>Methods: </strong>Thirty-two male stroke patients (55-85 years) were randomly assigned to four groups: A-ES, R-ES, ES, and control (CON). Over 8 weeks, participants in intervention groups completed three weekly sessions: aerobic or resistance training with FES, or FES alone. Blood samples were collected at baseline and 48 h post-intervention. vWF and IL-6 were measured by ELISA, ADAMTS13 by fluorimetry, and lipid profiles using the Selective Detergent method. Data were analyzed using mixed-model ANOVA.</p><p><strong>Results: </strong>Significant reductions in LDL-C, LDL-C/HDL-C ratio, IL-6, and vWF, along with increased ADAMTS13 activity, were observed in A-ES and R-ES groups (<i>p</i> < 0.05), with no significant change in HDL-C. No significant changes were found in ES or CON groups. Between-group comparisons showed significant effects only for vWF and LDL-C/HDL-C ratio, while interaction effects were significant for LDL-C, IL-6, vWF, and ADAMTS13.</p><p><strong>Conclusions: </strong>A-ES and R-ES improved inflammatory and hemostatic markers in men with ischemic stroke, showing similar efficacy. These benefits appear attributable to the aerobic and resistance components rather than FES, without evidence of synergistic effects.</p>","PeriodicalId":23164,"journal":{"name":"Topics in Stroke Rehabilitation","volume":" ","pages":"1-12"},"PeriodicalIF":2.5000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of combined aerobic and resistance training with functional electrical stimulation (FES) on inflammatory, hemostatic, and lipid profile markers in men after ischemic stroke: a randomized controlled trial.\",\"authors\":\"Morteza Mostaghimi, Ali Heidarianpour\",\"doi\":\"10.1080/10749357.2025.2566140\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Ischemic stroke is linked to endothelial dysfunction, inflammation, and disrupted hemostasis, particularly involving Von Willebrand factor (vWF), ADAMTS13, and pro-inflammatory cytokines. While functional electrical stimulation (FES) and exercise are used in stroke rehabilitation, the combined effects on inflammation and hemostatic markers remain unclear.</p><p><strong>Objectives: </strong>This study aimed to evaluate and compare the effects of aerobic-FES (A-ES), resistance-FES (R-ES), and FES alone on vWF, ADAMTS13 activity, interleukin-6 (IL-6), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in men with ischemic stroke.</p><p><strong>Methods: </strong>Thirty-two male stroke patients (55-85 years) were randomly assigned to four groups: A-ES, R-ES, ES, and control (CON). Over 8 weeks, participants in intervention groups completed three weekly sessions: aerobic or resistance training with FES, or FES alone. Blood samples were collected at baseline and 48 h post-intervention. vWF and IL-6 were measured by ELISA, ADAMTS13 by fluorimetry, and lipid profiles using the Selective Detergent method. Data were analyzed using mixed-model ANOVA.</p><p><strong>Results: </strong>Significant reductions in LDL-C, LDL-C/HDL-C ratio, IL-6, and vWF, along with increased ADAMTS13 activity, were observed in A-ES and R-ES groups (<i>p</i> < 0.05), with no significant change in HDL-C. No significant changes were found in ES or CON groups. Between-group comparisons showed significant effects only for vWF and LDL-C/HDL-C ratio, while interaction effects were significant for LDL-C, IL-6, vWF, and ADAMTS13.</p><p><strong>Conclusions: </strong>A-ES and R-ES improved inflammatory and hemostatic markers in men with ischemic stroke, showing similar efficacy. These benefits appear attributable to the aerobic and resistance components rather than FES, without evidence of synergistic effects.</p>\",\"PeriodicalId\":23164,\"journal\":{\"name\":\"Topics in Stroke Rehabilitation\",\"volume\":\" \",\"pages\":\"1-12\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Topics in Stroke Rehabilitation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10749357.2025.2566140\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"REHABILITATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Topics in Stroke Rehabilitation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10749357.2025.2566140","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"REHABILITATION","Score":null,"Total":0}
Effects of combined aerobic and resistance training with functional electrical stimulation (FES) on inflammatory, hemostatic, and lipid profile markers in men after ischemic stroke: a randomized controlled trial.
Background: Ischemic stroke is linked to endothelial dysfunction, inflammation, and disrupted hemostasis, particularly involving Von Willebrand factor (vWF), ADAMTS13, and pro-inflammatory cytokines. While functional electrical stimulation (FES) and exercise are used in stroke rehabilitation, the combined effects on inflammation and hemostatic markers remain unclear.
Objectives: This study aimed to evaluate and compare the effects of aerobic-FES (A-ES), resistance-FES (R-ES), and FES alone on vWF, ADAMTS13 activity, interleukin-6 (IL-6), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in men with ischemic stroke.
Methods: Thirty-two male stroke patients (55-85 years) were randomly assigned to four groups: A-ES, R-ES, ES, and control (CON). Over 8 weeks, participants in intervention groups completed three weekly sessions: aerobic or resistance training with FES, or FES alone. Blood samples were collected at baseline and 48 h post-intervention. vWF and IL-6 were measured by ELISA, ADAMTS13 by fluorimetry, and lipid profiles using the Selective Detergent method. Data were analyzed using mixed-model ANOVA.
Results: Significant reductions in LDL-C, LDL-C/HDL-C ratio, IL-6, and vWF, along with increased ADAMTS13 activity, were observed in A-ES and R-ES groups (p < 0.05), with no significant change in HDL-C. No significant changes were found in ES or CON groups. Between-group comparisons showed significant effects only for vWF and LDL-C/HDL-C ratio, while interaction effects were significant for LDL-C, IL-6, vWF, and ADAMTS13.
Conclusions: A-ES and R-ES improved inflammatory and hemostatic markers in men with ischemic stroke, showing similar efficacy. These benefits appear attributable to the aerobic and resistance components rather than FES, without evidence of synergistic effects.
期刊介绍：
Topics in Stroke Rehabilitation is the leading journal devoted to the study and dissemination of interdisciplinary, evidence-based, clinical information related to stroke rehabilitation. The journal’s scope covers physical medicine and rehabilitation, neurology, neurorehabilitation, neural engineering and therapeutics, neuropsychology and cognition, optimization of the rehabilitation system, robotics and biomechanics, pain management, nursing, physical therapy, cardiopulmonary fitness, mobility, occupational therapy, speech pathology and communication. There is a particular focus on stroke recovery, improving rehabilitation outcomes, quality of life, activities of daily living, motor control, family and care givers, and community issues.
The journal reviews and reports clinical practices, clinical trials, state-of-the-art concepts, and new developments in stroke research and patient care. Both primary research papers, reviews of existing literature, and invited editorials, are included. Sharply-focused, single-issue topics, and the latest in clinical research, provide in-depth knowledge.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
