{"title":"热应激相关疾病的翻译后修饰。","authors":"Qi Cui, Keran Jia, Fang Li, Jie Zheng, Fukun Wang","doi":"10.3389/fmolb.2025.1666874","DOIUrl":null,"url":null,"abstract":"<p><p>Post-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke. This review synthesizes evidence demonstrating that dynamic PTM networks-including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation-orchestrate pathophysiology through three distinctive mechanisms: PTM crosstalk, tissue-specific PTM signatures defining organ vulnerability, and translational utility. The potentials of PTM alterations as novel biomarkers for early diagnosis/prognosis and PTM-targeted interventions as therapeutic strategies are discussed. By delineating how PTMs reconfigure proteostasis, metabolism, and inflammation, this review provides a mechanistic framework for targeting PTM pathways to mitigate heatstroke and related conditions.</p>","PeriodicalId":12465,"journal":{"name":"Frontiers in Molecular Biosciences","volume":"12 ","pages":"1666874"},"PeriodicalIF":3.9000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497517/pdf/","citationCount":"0","resultStr":"{\"title\":\"Post-translational modifications in heat stress-related diseases.\",\"authors\":\"Qi Cui, Keran Jia, Fang Li, Jie Zheng, Fukun Wang\",\"doi\":\"10.3389/fmolb.2025.1666874\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Post-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke. This review synthesizes evidence demonstrating that dynamic PTM networks-including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation-orchestrate pathophysiology through three distinctive mechanisms: PTM crosstalk, tissue-specific PTM signatures defining organ vulnerability, and translational utility. The potentials of PTM alterations as novel biomarkers for early diagnosis/prognosis and PTM-targeted interventions as therapeutic strategies are discussed. By delineating how PTMs reconfigure proteostasis, metabolism, and inflammation, this review provides a mechanistic framework for targeting PTM pathways to mitigate heatstroke and related conditions.</p>\",\"PeriodicalId\":12465,\"journal\":{\"name\":\"Frontiers in Molecular Biosciences\",\"volume\":\"12 \",\"pages\":\"1666874\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497517/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Molecular Biosciences\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3389/fmolb.2025.1666874\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Molecular Biosciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fmolb.2025.1666874","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Post-translational modifications in heat stress-related diseases.
Post-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke. This review synthesizes evidence demonstrating that dynamic PTM networks-including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation-orchestrate pathophysiology through three distinctive mechanisms: PTM crosstalk, tissue-specific PTM signatures defining organ vulnerability, and translational utility. The potentials of PTM alterations as novel biomarkers for early diagnosis/prognosis and PTM-targeted interventions as therapeutic strategies are discussed. By delineating how PTMs reconfigure proteostasis, metabolism, and inflammation, this review provides a mechanistic framework for targeting PTM pathways to mitigate heatstroke and related conditions.
期刊介绍：
Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology.
Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life.
In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.
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