{"title":"一种集成Fe3O4@SiO2-Au纳米复合材料的磁性SERS适体传感器，用于高通量，敏感和选择性检测磺胺类药物。","authors":"Jinxin Liu, Zhili Gao, Han Fu, Cheng Tian, Pengfei Shi, Shusheng Zhang","doi":"10.1007/s00604-025-07568-1","DOIUrl":null,"url":null,"abstract":"<div><p> An innovative magnetic SERS aptasensor is presented that integrates Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-Au nanocomposites with aptamers, leveraging advancements in nanotechnology to overcome existing challenges. The aptasensor utilizes the magnetic Fe<sub>3</sub>O<sub>4</sub> core for efficient separation from complex samples and the Au-decorated SiO<sub>2</sub> shell for signal enhancement via localized surface plasmon resonance. Moreover, aptamers with specificity for sulaquinoxaline (SQ), sulfamethoxypyridazine (SMP), and sulfamethoxydiazine (SMD) were used to enable selective recognition. Under optimized conditions, the detection limits of the aptasensor achieved were LOD<sub>SQ</sub> = 33.26 pM, LOD<sub>SMD</sub> = 63.11 pM, and LOD<sub>SMP</sub> = 46.42 pM, with corresponding linear detection ranges of 0.1 nM to 50 μM, 0.1 nM to 50 μM, and 1 nM to 50 μM, respectively. It showed excellent selectivity against 11 interfering antibiotics and achieved recoveries of 91.4%–119.0% in real water samples (tap water, lake water, drinking water, seawater, effluent, river aquaculture water bodies, water bodies in lake poultry breeding areas, and milk). Moreover, the aptasensor demonstrates reliable performance in detecting sulfonamides in actual water samples, indicating its potential for applications in food safety and environmental monitoring.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 11","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A magnetic SERS aptasensor integrated with Fe3O4@SiO2-Au nanocomposites for high-throughput, sensitive, and selective detection of sulfonamides\",\"authors\":\"Jinxin Liu, Zhili Gao, Han Fu, Cheng Tian, Pengfei Shi, Shusheng Zhang\",\"doi\":\"10.1007/s00604-025-07568-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p> An innovative magnetic SERS aptasensor is presented that integrates Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-Au nanocomposites with aptamers, leveraging advancements in nanotechnology to overcome existing challenges. The aptasensor utilizes the magnetic Fe<sub>3</sub>O<sub>4</sub> core for efficient separation from complex samples and the Au-decorated SiO<sub>2</sub> shell for signal enhancement via localized surface plasmon resonance. Moreover, aptamers with specificity for sulaquinoxaline (SQ), sulfamethoxypyridazine (SMP), and sulfamethoxydiazine (SMD) were used to enable selective recognition. Under optimized conditions, the detection limits of the aptasensor achieved were LOD<sub>SQ</sub> = 33.26 pM, LOD<sub>SMD</sub> = 63.11 pM, and LOD<sub>SMP</sub> = 46.42 pM, with corresponding linear detection ranges of 0.1 nM to 50 μM, 0.1 nM to 50 μM, and 1 nM to 50 μM, respectively. It showed excellent selectivity against 11 interfering antibiotics and achieved recoveries of 91.4%–119.0% in real water samples (tap water, lake water, drinking water, seawater, effluent, river aquaculture water bodies, water bodies in lake poultry breeding areas, and milk). Moreover, the aptasensor demonstrates reliable performance in detecting sulfonamides in actual water samples, indicating its potential for applications in food safety and environmental monitoring.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"192 11\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-025-07568-1\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07568-1","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
A magnetic SERS aptasensor integrated with Fe3O4@SiO2-Au nanocomposites for high-throughput, sensitive, and selective detection of sulfonamides
An innovative magnetic SERS aptasensor is presented that integrates Fe3O4@SiO2-Au nanocomposites with aptamers, leveraging advancements in nanotechnology to overcome existing challenges. The aptasensor utilizes the magnetic Fe3O4 core for efficient separation from complex samples and the Au-decorated SiO2 shell for signal enhancement via localized surface plasmon resonance. Moreover, aptamers with specificity for sulaquinoxaline (SQ), sulfamethoxypyridazine (SMP), and sulfamethoxydiazine (SMD) were used to enable selective recognition. Under optimized conditions, the detection limits of the aptasensor achieved were LODSQ = 33.26 pM, LODSMD = 63.11 pM, and LODSMP = 46.42 pM, with corresponding linear detection ranges of 0.1 nM to 50 μM, 0.1 nM to 50 μM, and 1 nM to 50 μM, respectively. It showed excellent selectivity against 11 interfering antibiotics and achieved recoveries of 91.4%–119.0% in real water samples (tap water, lake water, drinking water, seawater, effluent, river aquaculture water bodies, water bodies in lake poultry breeding areas, and milk). Moreover, the aptasensor demonstrates reliable performance in detecting sulfonamides in actual water samples, indicating its potential for applications in food safety and environmental monitoring.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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