氨基酸催化邻苯二胺与α-酮酸合成苯并咪唑。

IF 4.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

RSC Advances Pub Date : 2025-10-06 DOI:10.1039/D5RA06371J

Zhenbiao Luo, Mulin Huang, Xiangyong Wang, Xinye Wang, Zhihui Hu, Liang Zhao and Ting Huang

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引用次数: 0

摘要

采用α-酮酸与邻苯二胺的氨基酸催化合成了一种绿色简便的苯并咪唑。该反应在空气和无金属催化剂条件下在水中顺利进行，得到2取代苯并咪唑。此外，该方法在室温下的开放系统中进行，使实验操作非常简单，大大提高了方法的可及性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of benzimidazoles from o-phenylenediamines with α-keto acids via amino acid catalysis

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Synthesis of benzimidazoles from o-phenylenediamines with α-keto acids via amino acid catalysis

A green and simple method for the synthesis of benzimidazoles by amino acid catalysis of o-phenylenediamines with α-keto acids has been developed. The reaction proceeded smoothly in water under air and metal catalyst-free conditions to obtain 2-substituted benzimidazoles. Furthermore, the method was performed in an open system at room temperature, making the experimental operation very simple and greatly enhancing the accessibility of the method.

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来源期刊

RSC Advances chemical sciences-

CiteScore

7.50

自引率

2.60%

发文量

3116

审稿时长

1.6 months

期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.