牛磺酸缺乏是人类衰老驱动因素的实验证据

IF 7.1 1区医学 Q1 Biochemistry, Genetics and Molecular Biology

Aging Cell Pub Date : 2025-08-11 DOI:10.1111/acel.70191

Vincent Marcangeli, Marina Cefis, Rami Hammad, Jordan Granet, Jean-Philippe Leduc-Gaudet, Pierrette Gaudreau, Mylène Aubertin-Leheudre, Marc Bélanger, Richard Robitaille, José A. Morais, Gilles Gouspillou

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引用次数: 0

摘要

牛磺酸缺乏最近被认为是包括人类在内的各种物种衰老的驱动因素。为了验证这一假设，我们评估了137名20-93岁之间不爱运动和不爱运动的男性的循环牛磺酸是否与衰老和身体表现有关。没有观察到循环牛磺酸水平与年龄、肌肉质量、力量、身体表现或线粒体功能之间的关联，因此质疑牛磺酸缺乏是人类衰老的主要驱动因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans

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Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans

Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged 20–93. No association between circulating taurine levels and age, muscle mass, strength, physical performance, or mitochondrial function was observed, thereby challenging the implication of taurine deficiency as a primary driver of aging in humans.

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来源期刊

Aging Cell 生物-老年医学

CiteScore

14.40

自引率

2.60%

发文量

212

审稿时长

8 weeks

期刊介绍： Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.