丙酸咪唑：动脉粥样硬化的病因与治疗？

IF 30.9 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-10-07 DOI:10.1016/j.cmet.2025.08.006

Xiangqi Chen, Xiaoqiang Tang, Yanping Li, Jinhan He

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引用次数: 0

摘要

动脉粥样硬化仍然是心血管疾病的主要类型，但其发病机制尚不完全清楚，阻碍了有效的早期诊断和治疗的发展。最近，Mastrangelo等人在《自然》杂志上的研究发现了一种新的动脉粥样硬化驱动因素，即肠道微生物衍生的代谢物咪唑丙酸盐，它通过髓细胞中的咪唑啉-1受体触发动脉粥样硬化。

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Imidazole propionate: Cause and cure in atherosclerosis?

Atherosclerosis remains the leading type of cardiovascular disease, yet its pathogenesis is not completely understood, hindering the development of effective early diagnostics and therapeutics. Recent work by Mastrangelo et al. in Nature has identified a novel driver of atherosclerosis, the gut microbiota-derived metabolite imidazole propionate, which triggers atherosclerosis via the imidazoline-1 receptor in myeloid cells.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.