破解组蛋白密码治疗前列腺癌。

IF 29 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-10-07 DOI:10.1038/s41588-025-02354-4

引用次数: 0

摘要

在这项研究中，我们揭示了p300/ cbp介导的组蛋白H2BN端多位点赖氨酸乙酰化（H2BNTac）在前列腺癌中定义致癌增强体的关键作用。p300/CBP的降解迅速禁用了h2bntac标记的致癌增强子，这代表了增强子驱动的恶性肿瘤（包括前列腺癌）的一种有希望的治疗策略。

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Cracking the histone code for prostate cancer therapy

In this study, we uncover the critical role of p300/CBP-mediated histone H2B N terminus multisite lysine acetylation (H2BNTac) in defining oncogenic enhanceosomes in prostate cancer. Degradation of p300/CBP rapidly disables H2BNTac-marked oncogenic enhancers and represents a promising therapeutic strategy for enhancer-driven malignancies, including prostate cancer.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution