Michael R Papazian, Melanie D Hicks, Kyle Mannion, Meghan Turner, Michael C Topf
{"title":"颈侧囊性肿块非诊断性FNA后HPV循环肿瘤DNA的诊断准确性。","authors":"Michael R Papazian, Melanie D Hicks, Kyle Mannion, Meghan Turner, Michael C Topf","doi":"10.1002/hed.70060","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cystic lateral neck masses in adults commonly represent nodal metastases from HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) or benign lesions. Because cystic lesions are relatively acellular, fine-needle aspiration (FNA) is often non-diagnostic. HPV circulating tumor DNA (ct-DNA) may aid diagnosis in these cases.</p><p><strong>Methods: </strong>We conducted a two-institution retrospective review of patients with cystic neck masses and non-diagnostic FNA who underwent pre-treatment HPV ct-DNA testing. Sensitivity, specificity, and predictive values were calculated based on final pathology.</p><p><strong>Results: </strong>Thirty-two patients were included. HPV ct-DNA was positive in 20/32 (62.5%) cases, all of which were HPV-associated OPSCC. Four patients with negative HPV ct-DNA were ultimately diagnosed with HPV-associated OPSCC (sensitivity: 83%, specificity: 100%, PPV: 100%, NPV: 67%).</p><p><strong>Conclusion: </strong>HPV ct-DNA demonstrated high specificity and may complement standard workup in adult cystic neck masses with non-diagnostic FNA. Positive HPV ct-DNA results should prompt further evaluation for HPV-associated OPSCC.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic Accuracy of HPV Circulating Tumor DNA Following Non-Diagnostic FNA of a Cystic Lateral Neck Mass.\",\"authors\":\"Michael R Papazian, Melanie D Hicks, Kyle Mannion, Meghan Turner, Michael C Topf\",\"doi\":\"10.1002/hed.70060\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cystic lateral neck masses in adults commonly represent nodal metastases from HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) or benign lesions. Because cystic lesions are relatively acellular, fine-needle aspiration (FNA) is often non-diagnostic. HPV circulating tumor DNA (ct-DNA) may aid diagnosis in these cases.</p><p><strong>Methods: </strong>We conducted a two-institution retrospective review of patients with cystic neck masses and non-diagnostic FNA who underwent pre-treatment HPV ct-DNA testing. Sensitivity, specificity, and predictive values were calculated based on final pathology.</p><p><strong>Results: </strong>Thirty-two patients were included. HPV ct-DNA was positive in 20/32 (62.5%) cases, all of which were HPV-associated OPSCC. Four patients with negative HPV ct-DNA were ultimately diagnosed with HPV-associated OPSCC (sensitivity: 83%, specificity: 100%, PPV: 100%, NPV: 67%).</p><p><strong>Conclusion: </strong>HPV ct-DNA demonstrated high specificity and may complement standard workup in adult cystic neck masses with non-diagnostic FNA. Positive HPV ct-DNA results should prompt further evaluation for HPV-associated OPSCC.</p>\",\"PeriodicalId\":55072,\"journal\":{\"name\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/hed.70060\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.70060","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Diagnostic Accuracy of HPV Circulating Tumor DNA Following Non-Diagnostic FNA of a Cystic Lateral Neck Mass.
Background: Cystic lateral neck masses in adults commonly represent nodal metastases from HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) or benign lesions. Because cystic lesions are relatively acellular, fine-needle aspiration (FNA) is often non-diagnostic. HPV circulating tumor DNA (ct-DNA) may aid diagnosis in these cases.
Methods: We conducted a two-institution retrospective review of patients with cystic neck masses and non-diagnostic FNA who underwent pre-treatment HPV ct-DNA testing. Sensitivity, specificity, and predictive values were calculated based on final pathology.
Results: Thirty-two patients were included. HPV ct-DNA was positive in 20/32 (62.5%) cases, all of which were HPV-associated OPSCC. Four patients with negative HPV ct-DNA were ultimately diagnosed with HPV-associated OPSCC (sensitivity: 83%, specificity: 100%, PPV: 100%, NPV: 67%).
Conclusion: HPV ct-DNA demonstrated high specificity and may complement standard workup in adult cystic neck masses with non-diagnostic FNA. Positive HPV ct-DNA results should prompt further evaluation for HPV-associated OPSCC.
期刊介绍：
Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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