Yao Zhang, Fei Zhang, Xiaoxiao Wu, Kunwei Ma, Jiong Li, Shijing Shi, Jiaxin Kang
{"title":"工程线粒体靶向近红外AIE荧光探针和图像引导光动力治疗。","authors":"Yao Zhang, Fei Zhang, Xiaoxiao Wu, Kunwei Ma, Jiong Li, Shijing Shi, Jiaxin Kang","doi":"10.1002/bio.70330","DOIUrl":null,"url":null,"abstract":"<p><p>Mitochondria play a very important role in the process of cell metabolism and apoptosis, and their morphology is closely related to the deterioration of some diseases. Aggregation-induced emission luminogens (AIEgens) are a promising biological imaging material due to their good stability and have been widely used in organelle targeting, localization, and tracking of cell metabolism. In this study, a near-infrared fluorescence molecule with aggregation-induced emission (AIE) properties was synthesized. The molecule has the characteristics of a large Stokes shift and good biocompatibility. This molecule can specifically target mitochondria in cells and can effectively produce ROS and kill cancer cells under white light irradiation, showing an excellent photodynamic therapy (PDT) effect in cells.</p>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 10","pages":"e70330"},"PeriodicalIF":3.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Engineering Mitochondria Targeting Near-Infrared AIE Fluorescent Probes and Image-Guided Photodynamic Therapy.\",\"authors\":\"Yao Zhang, Fei Zhang, Xiaoxiao Wu, Kunwei Ma, Jiong Li, Shijing Shi, Jiaxin Kang\",\"doi\":\"10.1002/bio.70330\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Mitochondria play a very important role in the process of cell metabolism and apoptosis, and their morphology is closely related to the deterioration of some diseases. Aggregation-induced emission luminogens (AIEgens) are a promising biological imaging material due to their good stability and have been widely used in organelle targeting, localization, and tracking of cell metabolism. In this study, a near-infrared fluorescence molecule with aggregation-induced emission (AIE) properties was synthesized. The molecule has the characteristics of a large Stokes shift and good biocompatibility. This molecule can specifically target mitochondria in cells and can effectively produce ROS and kill cancer cells under white light irradiation, showing an excellent photodynamic therapy (PDT) effect in cells.</p>\",\"PeriodicalId\":49902,\"journal\":{\"name\":\"Luminescence\",\"volume\":\"40 10\",\"pages\":\"e70330\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Luminescence\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1002/bio.70330\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Luminescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/bio.70330","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Mitochondria play a very important role in the process of cell metabolism and apoptosis, and their morphology is closely related to the deterioration of some diseases. Aggregation-induced emission luminogens (AIEgens) are a promising biological imaging material due to their good stability and have been widely used in organelle targeting, localization, and tracking of cell metabolism. In this study, a near-infrared fluorescence molecule with aggregation-induced emission (AIE) properties was synthesized. The molecule has the characteristics of a large Stokes shift and good biocompatibility. This molecule can specifically target mitochondria in cells and can effectively produce ROS and kill cancer cells under white light irradiation, showing an excellent photodynamic therapy (PDT) effect in cells.
期刊介绍：
Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry.
Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.
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