椰子油拔除和盐酸苄胺漱口水治疗放射性口腔黏膜炎的疗效:一项随机对照临床试验。

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
Journal of Maxillofacial & Oral Surgery Pub Date : 2025-10-01 Epub Date: 2025-03-20 DOI:10.1007/s12663-025-02515-2
Nancy Agarwal, Premalatha Shetty, Sameep Shetty, B Dhanashree, K M Sandeep
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引用次数: 0

摘要

口腔黏膜炎是一种令人疼痛和衰弱的口腔黏膜炎症,通常作为头颈癌患者放射治疗的急性副作用而发生。继发性感染(如念珠菌病)常使病情加重,使其治疗复杂化。虽然椰子油已经显示出有希望的治疗特性,特别是通过油拔的做法,但它在治疗或预防辐射引起的口腔黏膜炎方面的作用仍未经临床检验。方法:从芒格洛尔一家三级保健中心的放射治疗和肿瘤科共选择127例临床和组织病理学证实的口腔恶性肿瘤患者,计划进行放射治疗。该研究比较了两种干预措施:一组使用椰子油拔牙,另一组使用盐酸苄胺漱口水。在研究前后收集拭子样本,以评估念珠菌生长的减少情况。患者每两周评估一次粘膜炎、疼痛和牙关。在试验结束时,参与者完成了一份生活质量问卷,以进一步评估结果。结果:椰子油组假丝酵母菌菌落总数较治疗前和治疗后显著减少(p = 2.3 × 10-39)。此外,该组有明显的发病延迟和黏膜炎严重程度降低(p = 0.0000002)。疼痛显著改善(p = 0.006),生活质量总体提高(p = 0.009)。结论:椰子油拔牙具有显著的抗真菌、抗炎、镇痛作用,可有效减少和预防放射性口腔黏膜炎及其相关并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Coconut Oil Pulling and Benzydamine Hydrochloride Mouthwash in the Management of Radiation-Induced Oral Mucositis: a Randomized Controlled Clinical Trial.

Introduction: Oral mucositis is a painful and debilitating inflammation of the oral mucosa, commonly occurring as an acute side effect of radiation therapy in patients with head and neck cancer. The condition is often aggravated by secondary infections, such as candidiasis, complicating its management. Although coconut oil has shown promising therapeutic properties, particularly through the practice of oil pulling, its role in the treatment or prevention of radiation-induced oral mucositis remains clinically unexamined.

Method: A total of 127 individuals with clinically and histopathologically confirmed oral malignancies, scheduled for radiation therapy, were selected from the Radiotherapy and Oncology Department of a tertiary care centre in Mangalore. The study compared two interventions: coconut oil pulling in one group and benzydamine hydrochloride mouthwash (Tantum) in the other. Swab samples were collected before and after the study to assess the reduction in candida growth. Patients were evaluated biweekly for mucositis, pain, and trismus. At the end of the trial, participants completed a quality of life questionnaire to further assess the outcomes.

Results: The coconut oil group demonstrated a statistically significant reduction in the total colony count of Candida species from pre to post-treatment (p = 2.3 × 10-39). Additionally, there was a notable delay in the onset and a reduction in the severity of mucositis in this group (p = 0.0000002). Significant improvements were observed in pain (p < 0.001), and trismus (p = 0.006) alongside an overall enhancement in the quality of life (p = 0.009).

Conclusion: Coconut oil pulling exhibited significant antifungal, anti-inflammatory, and analgesic properties, effectively reducing and preventing radiation-induced oral mucositis and its associated complications.

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来源期刊
Journal of Maxillofacial & Oral Surgery
Journal of Maxillofacial & Oral Surgery DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
1.90
自引率
0.00%
发文量
138
期刊介绍: This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.
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