Nancy Agarwal, Premalatha Shetty, Sameep Shetty, B Dhanashree, K M Sandeep
{"title":"椰子油拔除和盐酸苄胺漱口水治疗放射性口腔黏膜炎的疗效:一项随机对照临床试验。","authors":"Nancy Agarwal, Premalatha Shetty, Sameep Shetty, B Dhanashree, K M Sandeep","doi":"10.1007/s12663-025-02515-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Oral mucositis is a painful and debilitating inflammation of the oral mucosa, commonly occurring as an acute side effect of radiation therapy in patients with head and neck cancer. The condition is often aggravated by secondary infections, such as candidiasis, complicating its management. Although coconut oil has shown promising therapeutic properties, particularly through the practice of oil pulling, its role in the treatment or prevention of radiation-induced oral mucositis remains clinically unexamined.</p><p><strong>Method: </strong>A total of 127 individuals with clinically and histopathologically confirmed oral malignancies, scheduled for radiation therapy, were selected from the Radiotherapy and Oncology Department of a tertiary care centre in Mangalore. The study compared two interventions: coconut oil pulling in one group and benzydamine hydrochloride mouthwash (Tantum) in the other. Swab samples were collected before and after the study to assess the reduction in candida growth. Patients were evaluated biweekly for mucositis, pain, and trismus. At the end of the trial, participants completed a quality of life questionnaire to further assess the outcomes.</p><p><strong>Results: </strong>The coconut oil group demonstrated a statistically significant reduction in the total colony count of Candida species from pre to post-treatment (<i>p</i> = 2.3 × 10<sup>-39</sup>). Additionally, there was a notable delay in the onset and a reduction in the severity of mucositis in this group (<i>p</i> = 0.0000002). Significant improvements were observed in pain (<i>p</i> < 0.001), and trismus (<i>p</i> = 0.006) alongside an overall enhancement in the quality of life (<i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>Coconut oil pulling exhibited significant antifungal, anti-inflammatory, and analgesic properties, effectively reducing and preventing radiation-induced oral mucositis and its associated complications.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 5","pages":"1343-1350"},"PeriodicalIF":0.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496380/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of Coconut Oil Pulling and Benzydamine Hydrochloride Mouthwash in the Management of Radiation-Induced Oral Mucositis: a Randomized Controlled Clinical Trial.\",\"authors\":\"Nancy Agarwal, Premalatha Shetty, Sameep Shetty, B Dhanashree, K M Sandeep\",\"doi\":\"10.1007/s12663-025-02515-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Oral mucositis is a painful and debilitating inflammation of the oral mucosa, commonly occurring as an acute side effect of radiation therapy in patients with head and neck cancer. The condition is often aggravated by secondary infections, such as candidiasis, complicating its management. Although coconut oil has shown promising therapeutic properties, particularly through the practice of oil pulling, its role in the treatment or prevention of radiation-induced oral mucositis remains clinically unexamined.</p><p><strong>Method: </strong>A total of 127 individuals with clinically and histopathologically confirmed oral malignancies, scheduled for radiation therapy, were selected from the Radiotherapy and Oncology Department of a tertiary care centre in Mangalore. The study compared two interventions: coconut oil pulling in one group and benzydamine hydrochloride mouthwash (Tantum) in the other. Swab samples were collected before and after the study to assess the reduction in candida growth. Patients were evaluated biweekly for mucositis, pain, and trismus. At the end of the trial, participants completed a quality of life questionnaire to further assess the outcomes.</p><p><strong>Results: </strong>The coconut oil group demonstrated a statistically significant reduction in the total colony count of Candida species from pre to post-treatment (<i>p</i> = 2.3 × 10<sup>-39</sup>). Additionally, there was a notable delay in the onset and a reduction in the severity of mucositis in this group (<i>p</i> = 0.0000002). Significant improvements were observed in pain (<i>p</i> < 0.001), and trismus (<i>p</i> = 0.006) alongside an overall enhancement in the quality of life (<i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>Coconut oil pulling exhibited significant antifungal, anti-inflammatory, and analgesic properties, effectively reducing and preventing radiation-induced oral mucositis and its associated complications.</p>\",\"PeriodicalId\":47495,\"journal\":{\"name\":\"Journal of Maxillofacial & Oral Surgery\",\"volume\":\"24 5\",\"pages\":\"1343-1350\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496380/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Maxillofacial & Oral Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12663-025-02515-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Maxillofacial & Oral Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12663-025-02515-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/20 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Effect of Coconut Oil Pulling and Benzydamine Hydrochloride Mouthwash in the Management of Radiation-Induced Oral Mucositis: a Randomized Controlled Clinical Trial.
Introduction: Oral mucositis is a painful and debilitating inflammation of the oral mucosa, commonly occurring as an acute side effect of radiation therapy in patients with head and neck cancer. The condition is often aggravated by secondary infections, such as candidiasis, complicating its management. Although coconut oil has shown promising therapeutic properties, particularly through the practice of oil pulling, its role in the treatment or prevention of radiation-induced oral mucositis remains clinically unexamined.
Method: A total of 127 individuals with clinically and histopathologically confirmed oral malignancies, scheduled for radiation therapy, were selected from the Radiotherapy and Oncology Department of a tertiary care centre in Mangalore. The study compared two interventions: coconut oil pulling in one group and benzydamine hydrochloride mouthwash (Tantum) in the other. Swab samples were collected before and after the study to assess the reduction in candida growth. Patients were evaluated biweekly for mucositis, pain, and trismus. At the end of the trial, participants completed a quality of life questionnaire to further assess the outcomes.
Results: The coconut oil group demonstrated a statistically significant reduction in the total colony count of Candida species from pre to post-treatment (p = 2.3 × 10-39). Additionally, there was a notable delay in the onset and a reduction in the severity of mucositis in this group (p = 0.0000002). Significant improvements were observed in pain (p < 0.001), and trismus (p = 0.006) alongside an overall enhancement in the quality of life (p = 0.009).
Conclusion: Coconut oil pulling exhibited significant antifungal, anti-inflammatory, and analgesic properties, effectively reducing and preventing radiation-induced oral mucositis and its associated complications.
期刊介绍:
This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.