一项评估口腔舌癌感觉失调与不良病理特征相关性的前瞻性研究。

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
Journal of Maxillofacial & Oral Surgery Pub Date : 2025-10-01 Epub Date: 2024-12-10 DOI:10.1007/s12663-024-02410-2
Arjun Gurmeet Singh, Mihir Dani, Shwetabh Sinha, Rathan Shetty, Poonam Joshi, Sudhir Nair, Pankaj Chaturvedi
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引用次数: 0

摘要

目的:探讨舌癌患者感觉功能障碍与不良病理因素的相关性,并确定其预后因素。方法:前瞻性收集2021年7月至2022年9月间接受手术治疗的口腔舌鳞癌患者的疼痛感觉(Brief pain Inventory)、味觉(NIH Taste Intensity Test)、本体感觉(Two-point and light - touch discrimination)数据,并根据pT分期进行分层。病理学家对临床数据不知情,并通过多变量分析获得与感觉失调的相关性。采用Kaplan-Meier法计算预测总生存期(OS)和疾病特异性生存期(DSS)的因素。结果:100例患者随访,中位时间13个月。放射疼痛预测疾病进展、结外延伸(ENE)和神经周围浸润(PNI)。甜味和咸味的丧失与疾病晚期、脱毛和PNI有关。在早期肿瘤中,26%有味觉改变,甜味丧失与脱毛和PNI显著相关。轻触的丧失与PNI的存在显著相关,而两点辨别的丧失与较大的肿瘤、PNI和较差的分级相关。当疼痛评分为中度至重度且至少在访谈后24小时内失去轻触时,OS显著降低。结论:放射痛、甜咸味觉失调和感觉辨别能力丧失与PNI有较强的相关性,影响生存。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Prospective Study to Evaluate the Association of Sensory Dysregulation and Adverse Pathologic Features in Oral Tongue Cancers.

Objectives: To correlate sensory dysfunction with adverse pathologic factors for tongue cancers and determine the survival prognosticators.

Methods: We prospectively collected data on the pain sensation (Brief Pain Inventory), gustation (NIH Taste Intensity Test), proprioception (Two-point and light touch discrimination) from patients with squamous carcinoma of oral tongue, surgically treated between July 2021 and September 2022, and stratified them based on pT stage. The pathologist was blinded to the clinical data and correlation with the sensory dysregulations was obtained using a multivariate analysis. Factors predicting overall survival (OS) and disease specific survival (DSS) were calculated using Kaplan-Meier method.

Results: 100 patients were followed up with a median of 13 months. Radiating pain predicted advanced disease, extranodal extension (ENE) and perineural invasion (PNI). Loss of sweet and salty taste were associated with advanced disease, Depapillation and PNI. Among early tumors, 26% had taste alterations, with loss of sweet taste significantly associated with Depapillation and PNI. Loss of light touch was significantly associated with presence of PNI, while loss of two-point discrimination was associated with larger tumors, PNI and poor grade. The OS was significantly reduced when pain scores were moderate to severe at their least within 24 h from interview and loss of light touch.

Conclusion: Radiating pain, sweet and salty taste dysregulation and loss of sensory discrimination have a strong correlation with PNI and impact survival.

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来源期刊
Journal of Maxillofacial & Oral Surgery
Journal of Maxillofacial & Oral Surgery DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
1.90
自引率
0.00%
发文量
138
期刊介绍: This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.
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