间歇性艾司西酞普兰治疗对经前烦躁和愤怒女性冲动和注意力不集中的影响。

IF 5.5 2区 医学 Q1 PSYCHIATRY
Maria Gröndal, Christin Englund, Jakob Näslund, Karl Ask, Elias Eriksson, Stefan Winblad
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引用次数: 0

摘要

背景:经前烦躁不安(PMDD)的女性在接受选择性5 -羟色胺再摄取抑制剂治疗后,症状明显缓解,但很少有研究表明,在行为和实验室测试中捕捉到这种效果的可能性。本研究考察了艾司西酞普兰间歇治疗(与安慰剂对照)对报告高水平经前易怒和愤怒的女性冲动和注意力不集中的行为测量的影响。方法:参与者(N = 27)在三个月经周期内使用视觉模拟量表评定经前不悦症的主要情绪症状。在第2和第3个周期中,在随机、单盲、交叉设计中,对烦躁/愤怒项目表现出周期性的参与者服用艾司西酞普兰(20mg)或安慰剂。参与者在干预周期的黄体期完成了Conners连续表现测试(CPT 3)。此外,他们填写了UPPS冲动行为量表,一次在黄体期,一次在安慰剂周期的卵泡期。结果:与先前的报道一致,艾司西酞普兰引起黄体期自评易怒和愤怒的显著减少。当服用艾司西酞普兰时,参与者在CPT 3中表现出更低的预期反应频率和更大的反应速度一致性。在自我报告的冲动方面,参与者报告在黄体安慰剂期比卵泡期有更高水平的紧迫感和更低水平的感觉寻求。结论:艾司西酞普兰影响经前易怒女性CPT 3测试结果的发现,强调了冲动在这种情况下可能起的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of intermittent escitalopram treatment on impulsivity and inattention in women with premenstrual irritability and anger.

Background: Women diagnosed with premenstrual dysphoric disorder (PMDD) report significant symptom relief when treated with selective serotonin reuptake inhibitors, but few studies have addressed the possibility of capturing this effect in behavioral, laboratory-based tests. This study examined the effects of intermittent treatment with escitalopram (vs. placebo) on a behavioral measure of impulsivity and inattentiveness in women reporting high levels of premenstrual irritability and anger.

Methods: Participants (N = 27) rated cardinal PMDD mood symptoms over three menstrual cycles using Visual Analogue Scales. In Cycles 2 and 3, participants displaying cyclicity with respect to the irritability/anger item received escitalopram (20 mg) or placebo in a randomized, single-blind, crossover design. The participants completed the Conners Continuous Performance Test (CPT 3) in the luteal phase of the intervention cycles. Additionally, they filled out the UPPS Impulsive Behavior Scale, once in the luteal phase and once in the follicular phase of the placebo cycle.

Results: In line with previous reports, escitalopram caused a significant reduction in self-rated irritability and anger in the luteal phase. When on escitalopram, the participants demonstrated a lower frequency of anticipatory responses and greater consistency in response speed in the CPT 3. With respect to self-reported impulsivity, participants reported higher levels of urgency and lower levels of sensation seeking in the luteal placebo phase versus the follicular phase.

Conclusions: The finding that escitalopram impacted the outcome of the CPT 3 test in women with premenstrual irritability highlights the possible role of impulsivity in this condition.

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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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