{"title":"细胞外囊泡在子宫内膜癌细胞和肿瘤相关巨噬细胞之间的通讯中的作用：综述。","authors":"Feng Li, Wei Shi","doi":"10.1007/s00432-025-06318-3","DOIUrl":null,"url":null,"abstract":"<p><p>Endometrial cancer is a significant threat to the health of women worldwide. Extracellular vesicles are essential for the proliferation, migration, and invasion of cancer cells, whereas tumour-associated macrophages (TAMs) are key regulators of cancer development. The interaction between macrophages and extracellular vesicles is also important in endometrial cancer. Extracellular vesicles from endometrial cancer cells can promote the polarization of macrophages towards an M2-like phenotype, and those from macrophages can also decrease the sensitivity of endometrial cancer cells to radiation. This paper presents a review of the various roles of extracellular vesicles in endometrial cancer and their potential as biomarkers and therapeutic targets. Research progress on the communication between endometrial cancer cells and tumour-associated macrophages mediated by extracellular vesicles is reviewed as well.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"151 11","pages":"286"},"PeriodicalIF":2.8000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504176/pdf/","citationCount":"0","resultStr":"{\"title\":\"The role of extracellular vesicles in the communication between endometrial cancer cells and tumour-associated macrophages: a review.\",\"authors\":\"Feng Li, Wei Shi\",\"doi\":\"10.1007/s00432-025-06318-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Endometrial cancer is a significant threat to the health of women worldwide. Extracellular vesicles are essential for the proliferation, migration, and invasion of cancer cells, whereas tumour-associated macrophages (TAMs) are key regulators of cancer development. The interaction between macrophages and extracellular vesicles is also important in endometrial cancer. Extracellular vesicles from endometrial cancer cells can promote the polarization of macrophages towards an M2-like phenotype, and those from macrophages can also decrease the sensitivity of endometrial cancer cells to radiation. This paper presents a review of the various roles of extracellular vesicles in endometrial cancer and their potential as biomarkers and therapeutic targets. Research progress on the communication between endometrial cancer cells and tumour-associated macrophages mediated by extracellular vesicles is reviewed as well.</p>\",\"PeriodicalId\":15118,\"journal\":{\"name\":\"Journal of Cancer Research and Clinical Oncology\",\"volume\":\"151 11\",\"pages\":\"286\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504176/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cancer Research and Clinical Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00432-025-06318-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cancer Research and Clinical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00432-025-06318-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
The role of extracellular vesicles in the communication between endometrial cancer cells and tumour-associated macrophages: a review.
Endometrial cancer is a significant threat to the health of women worldwide. Extracellular vesicles are essential for the proliferation, migration, and invasion of cancer cells, whereas tumour-associated macrophages (TAMs) are key regulators of cancer development. The interaction between macrophages and extracellular vesicles is also important in endometrial cancer. Extracellular vesicles from endometrial cancer cells can promote the polarization of macrophages towards an M2-like phenotype, and those from macrophages can also decrease the sensitivity of endometrial cancer cells to radiation. This paper presents a review of the various roles of extracellular vesicles in endometrial cancer and their potential as biomarkers and therapeutic targets. Research progress on the communication between endometrial cancer cells and tumour-associated macrophages mediated by extracellular vesicles is reviewed as well.
期刊介绍：
The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses.
The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.
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