1h -吡唑C-H/N-H功能化的合成进展：不同取代支架的不同策略。

IF 7.5 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical record Pub Date : 2025-10-07 DOI:10.1002/tcr.202500024

Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė

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引用次数: 0

摘要

本文简要系统地综述了吡唑的C- h和N-H功能化反应，目的是在吡唑环上形成新的C- _ - C和C- _ - h杂原子键。它讨论了各种策略，包括需要预官能化吡唑的传统交叉偶联反应以及直接官能化反应，后者提供了一种更有效的方法，只需一步即可获得多种官能化衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Synthetic Advances in C-H/N-H Functionalization of 1H-Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds.

This review briefly and systematically overviews C-H and N-H functionalization reactions of pyrazoles, aimed at creating new CC and Cheteroatom bonds on the pyrazole ring. It discusses various strategies, including traditional cross-coupling reactions that necessitate prefunctionalized pyrazoles as well as direct functionalization reactions, which offer a more efficient approach to obtaining a diverse array of functionalized derivatives in only one step.

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.